increase in kappa free light chains and in ratio with lambda Lt chains

You don't mention whether you have any other conditions or if you're on any meds. What does your doctor say about the current numbers? I have SMM which was diagnosed while I was on prednisone for PMR, and my Kappa lambda ratio has increased from 8.12 to 10.26 since I have been on prednisone, but it's possible that the prednisone is affecting my kappa and lambda numbers differently and causing the change in ratio. I'm on a fast taper off prednisone and won't know for sure until I get to 5mg, which no longer significantly affects my SMM blood work. I'm concerned but optimistic that my new blood work next month will show that I'm still in the SMM range, and not MM.

I was diagnosed with MGUS 10 years ago and it started ramping up 3 years ago, after getting covid. I'm in SMM range now with an M spike of 1.4 (problematic when 2 or higher), kappa/lambda of 93 (preferably below 20), and kappa of 1,290 (1.65 and less is better), but still not high enough for standard treatment. You are in the wait and see mode, bloodwork every 6 mo to see if your numbers ramp up or stay stable. MGUS does not progress to MM for most people. Next month I will likely start a clinical trial with bispecific antibodies (generally used with refractory and stage 4 MM), to see if progression to MM can be stopped or slowed by years. I had a baseline BMB (bone marrow biopsy) 10 years ago with 5% deranged cells (normal about 2.5% and less), MGUS range. My BMB two years ago was 16%. Things to consider are healthy diet, exercise (weights and aerobic), and managing stress. Having supportive friends/family is good too, even without illnesses. Some people with MGUS/SMM/MM take bioavailable curcuminoids found in turmeric, initial research suggests that at elevated doses the curcumin can slow tumor growth. Whether it works for us is mixed because it is very poorly absorbed (check with a natural grocery store on pill options). https://www.cancer.gov/about-cancer/treatment/cam/hp/curcumin-pdq