1. < Breast Cancer

Concerned about the side effects of anastrozole

Posted by tinalove @tinalove, Jan 31, 2016

I completed all treatments for breast cancer but now I am supposed to take hormone blocker, named anastrozole. im concerned about the side effects. Has anyone here taken it and did anyone have hair loss?

Interested in more discussions like this? Go to the Breast Cancer Support Group.

jejones | @jejones | Jun 21, 2021
In reply to @sandyrob "Yes, same doctor. I have Stage1a, IDC, Pr+ Es+, Her2- . Could have opted out of..." + (show)
@sandyrob

Yes, same doctor. I have Stage1a, IDC, Pr+ Es+, Her2- . Could have opted out of radiation but am doing the 3 day.

Jump to this post

Sounds like great decision!! Blessings on you!

REPLY
alice2oz | @alice2oz | Jun 21, 2021

I am Her2+ER-. Diagnosed Mets in 2018 in Liver. Lesions NAD on Herceptin Perjeta. Now new lesion in Duodenum. On Kadcyla, and needed duodenal stent as lesion was causing blockage. Lesion again stable (NAD on last 2 PET scans. ) A Whipple procedure has been recommended as it is felt they can remove the remaining tumour with clear margins. The surgery souds terrifying
Any thoughts?

REPLY
1 reply
sandyrob | @sandyrob | Jun 21, 2021
In reply to @jejones "The higher dose definitely lowered my estrogen after 8 weeks. It was 10mg. I had more..." + (show)
@jejones

The higher dose definitely lowered my estrogen after 8 weeks. It was 10mg. I had more hot flashes and initially, poor sleep. And about 4 weeks in, I started losing my hair (maybe 5-10 strands a day, but definitely more than usual.) Now I am on Letrozole, since end Dec. Hair loss has continued, but I am sleeping and hot flashes are less.

Any chance your oncologist is Dr G at Mayo? Your process is so similar to mine and he is good at getting people on the study.

Jump to this post

Yes, same doctor. I have Stage1a, IDC, Pr+ Es+, Her2- . Could have opted out of radiation but am doing the 3 day.

REPLY
1 reply
Moderator
Colleen Young, Connect Director | @colleenyoung | Jun 21, 2021
In reply to @auksst "Not sure what kind of breast cancer you have but if you have DCIS low dose..." + (show)
@auksst

Not sure what kind of breast cancer you have but if you have DCIS low dose tamoxifen may be an option. I am unable to post the link to breastcancer.org that has information on this.

Jump to this post

Hi Auksst, I noticed that you wished to post a URL to a resource with your post. You will be able to add URLs to your posts in a few days. There is a brief period where new members can't post links. We do this to deter spammers and keep the community safe. Clearly the link you wanted to post is not spam. Please allow me to post it for you.

- Low-Dose Tamoxifen May Be an Option to Reduce Risk of Recurrence, Invasive Disease After Non-Invasive Breast Cancer https://www.breastcancer.org/research-news/low-dose-tamoxifen-after-non-invasive-dx

REPLY
auksst | @auksst | Jun 21, 2021
In reply to @cedar75 "When I asked about estrogen hormonal levels I got the answer they really do not know..." + (show)
@cedar75

When I asked about estrogen hormonal levels I got the answer they really do not know what levels mean. If they were going to do levels they should have done a baseline before starting the drug. My frustration with A1 drugs is not only do they have significant side effects but despite thousands of women who are on these drugs they seem unable to state which women are at risk for side effects. Is it age, is it type of breast cancer, is it BMI, is it women who still have their ovaries. I am glad to see that someone is looking at dosage of these drugs because the concept of one size dose fits all seems not very scientific. Can you have the same efficacy at lower doses. Would lower doses mean lower side effects. The fact that 30-40% of women quit this therapy because of side effects is mind boggling. I have this feeling that all they want to do is treat side effects with other meds that have side effects instead of really looking at who is at risk and how to improve this therapy

Jump to this post

Not sure what kind of breast cancer you have but if you have DCIS low dose tamoxifen may be an option. I am unable to post the link to breastcancer.org that has information on this.

REPLY
1 reply
sequoia | @sequoia | Jun 19, 2021
In reply to @cedar75 "When I asked about estrogen hormonal levels I got the answer they really do not know..." + (show)
@cedar75

When I asked about estrogen hormonal levels I got the answer they really do not know what levels mean. If they were going to do levels they should have done a baseline before starting the drug. My frustration with A1 drugs is not only do they have significant side effects but despite thousands of women who are on these drugs they seem unable to state which women are at risk for side effects. Is it age, is it type of breast cancer, is it BMI, is it women who still have their ovaries. I am glad to see that someone is looking at dosage of these drugs because the concept of one size dose fits all seems not very scientific. Can you have the same efficacy at lower doses. Would lower doses mean lower side effects. The fact that 30-40% of women quit this therapy because of side effects is mind boggling. I have this feeling that all they want to do is treat side effects with other meds that have side effects instead of really looking at who is at risk and how to improve this therapy

Jump to this post

Absolutely right! Thank you for your comment. It summarizes my questions perfectly. I’m going to keep asking questions. Like you said, I don’t believe I EVEN have a baseline. You would think that if they know the cancer was estrogen positive, they would be check my ‘levels’. 🤷‍♀️

REPLY
jejones | @jejones | Jun 18, 2021
In reply to @sandyrob "How did you do on the higher dose of Anastrozole?" + (show)
@sandyrob

How did you do on the higher dose of Anastrozole?

Jump to this post

The higher dose definitely lowered my estrogen after 8 weeks. It was 10mg. I had more hot flashes and initially, poor sleep. And about 4 weeks in, I started losing my hair (maybe 5-10 strands a day, but definitely more than usual.) Now I am on Letrozole, since end Dec. Hair loss has continued, but I am sleeping and hot flashes are less.

Any chance your oncologist is Dr G at Mayo? Your process is so similar to mine and he is good at getting people on the study.

REPLY
1 reply
cedar75 | @cedar75 | Jun 18, 2021

When I asked about estrogen hormonal levels I got the answer they really do not know what levels mean. If they were going to do levels they should have done a baseline before starting the drug. My frustration with A1 drugs is not only do they have significant side effects but despite thousands of women who are on these drugs they seem unable to state which women are at risk for side effects. Is it age, is it type of breast cancer, is it BMI, is it women who still have their ovaries. I am glad to see that someone is looking at dosage of these drugs because the concept of one size dose fits all seems not very scientific. Can you have the same efficacy at lower doses. Would lower doses mean lower side effects. The fact that 30-40% of women quit this therapy because of side effects is mind boggling. I have this feeling that all they want to do is treat side effects with other meds that have side effects instead of really looking at who is at risk and how to improve this therapy

REPLY
2 replies
sequoia | @sequoia | Jun 18, 2021
In reply to @jejones "It was a blood draw for me that told the oncologist that my estrogen was low..." + (show)
@jejones

It was a blood draw for me that told the oncologist that my estrogen was low enough. But it is frustrating when they can't tell you the exact number you have ..and what is acceptable. Keep pushing!!!!

Jump to this post

Thank you jejones. Blood test scheduled for June 24

REPLY
1 reply
sandyrob | @sandyrob | Jun 18, 2021
In reply to @jejones "That study will have them checking your estrogen levels more often. I was on a study..." + (show)
@jejones

That study will have them checking your estrogen levels more often. I was on a study last year. I hope that the 1 mg pill will reduce your estrogen level low enough. It does for most people (but not for me, so I had to go on the heavier dose of Anastrozole !!! ) All the best!!

Jump to this post

How did you do on the higher dose of Anastrozole?

REPLY
1 reply
View MoreView Less
Please sign in or register to post a reply.