The higher dose definitely lowered my estrogen after 8 weeks. It was 10mg. I had more hot flashes and initially, poor sleep. And about 4 weeks in, I started losing my hair (maybe 5-10 strands a day, but definitely more than usual.) Now I am on Letrozole, since end Dec. Hair loss has continued, but I am sleeping and hot flashes are less.

Any chance your oncologist is Dr G at Mayo? Your process is so similar to mine and he is good at getting people on the study.

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