Hypothyroidism: What medications work for you?

Posted by melbutts61 @melbutts61, Jul 13, 2025

I was curious if there are better medications out there for Hypothyroidism. I have been on Synthroid for 18 years and of course my lab work looks fine but I do not feel fine. Anybody else experiencing the same?

Interested in more discussions like this? Go to the Diabetes & Endocrine System Support Group.

the book, Stop the Thyroid Madness, is quite informative, too.

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Profile picture for skyhollow @skyhollow

I did not do well on Synthroid. I take NP thyroid , which is a desiccated thyroid with both T3 and T4 in it. I also take a small amount of compounded thyroid medication ,too, that has T3 and T4 in it as well.
Read books by Izabella Wentz. She is a registered pharmacist who delves deeply into thyroid management.

I also take vitamin D3, selenium and zinc-all required for your thyroid to work optimally.

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@skyhollow
I read a lot from posters having issues with thyroid medications. I am on a very low dose but have never had any side effects from it. I take only 12.5 mg of it which is half of the tablet it comes in. I take the generic form Synthroid.

With only being able to pass on my personal experience with the side effects I have had (which are none) can you go into what your side effects were? Did those side effects listed on the medication information sheet?

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Profile picture for jc76 @jc76

@skyhollow
I read a lot from posters having issues with thyroid medications. I am on a very low dose but have never had any side effects from it. I take only 12.5 mg of it which is half of the tablet it comes in. I take the generic form Synthroid.

With only being able to pass on my personal experience with the side effects I have had (which are none) can you go into what your side effects were? Did those side effects listed on the medication information sheet?

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I can't say I had side effects. I just didn't feel well on it.

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My husband is going through the same thing. I am currently looking into bovine thyroid supplement 130mg from new Zealand. Google it. Good look 🫂🙏

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Profile picture for skyhollow @skyhollow

I can't say I had side effects. I just didn't feel well on it.

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@skyhollow
What are your feelings like? Have you discussed them with your cardiologist?

I recently had my Synthroid raised from half a 25 tablet to each day to a whole one. I am experiencing some new fatigue and sleepiness. I would have thought the opposite would happen as more would cause increased in metabolism.

Not sure if this is from the increase in Synthroid but is the only change in my medications.

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