HRT levels for transfemme persons

Welcome @bobbie4481. You're asking good questions. However, I think this might be best asked of the health care team supporting your transition. Do you have a doctor working with you and supportive with gender-affirming care?

@jeri444 mentioned the organization Plume (https://getplume.co/) in another discussion. It may be worth exploring.

Bobbie, how are feeling with your current levels?

I have both a primary care physician and an endocrinologist. My PCP doesn't have a lot of experience with transgender patients my age (I know I'm really late to the party). The same is true for my endocrinologist. I've been trying to find objective data for individuals later in life's journey.
The first six months went pretty much as expected with skin softening, early breast development and renewed hair growth where it once was thinning. My first endocrinologist decided to reduce my E dosage and double my Spiro dosage to crash my T counts. It certainly accomplished that, but simultaneously crashed my E counts from a comfortable 196 to 90. Breast development stopped. I fired that endocrinologist and current one bumped my patches to 3, twice weekly and reduced spiro to 100 mg. She then added 2.5 mg progesterone.
I began that regimen in November. The only result is significant night sweats, every night. No additional physical changes have been noted. My current endocrinologist wants me to stop all estradiol for a week, begin 2 patches twice weekly thereafter and get new labs pulled in four weeks. Spiro and progesterone dosage remains the same. She thinks my current E levels are "way too high" and that reducing them will likely eliminate the night sweats and get my levels back to where she is comfortable.
So I ask the question again, what should E and T levels are optimal for someone my age, who is in good health?
Members of a transgender support group I belong to report E levels in the mid 200s to 300. They are much younger than I am.

Hello,
I am male to female trans, intersex woman. I am 62 years on.
In order to see physical changes you need estrogen levels equal to a teenager in puberty. Changes take three to five years to complete as they do in puberty. Progesterone Im told should begin about a year after estrogen starts. Progesterone and estrogen work together. Not just for breast development, but also heart and bone health, and likely more.
I personally take estrogen by weekly injection at .06ml. But each persons requirement is different. Im told blockers are bad for me. If you are intending to transition, why not just remove the source of testosterone and skip the blockers all together ?

They say around 300 is what they want you at or less but I had once a reading of 2,900 in my blood for three months before I went back to my hurt doctor with no ill affects didn’t even grow my breasts!?. Ronnie !

Since my January post, much has changed. I was finally able to meet with the only WPATH certified physician in western Michigan (a 3 hour drive each way, but well worth the effort). After pulling new labs, he made a number of recommendations, all of which my VA endocrinologist reluctantly agreed to. My April labs were getting back on track, my night sweats have stopped almost completely, breast development has improved and my mood swings have stabilized. E was up to 269, so the endocrinologist wanted me to reduce my estrogen. I told her WPATH standards can go as high as 400 without issues, based on my health profile (excellent for a 70 year old). New labs are scheduled for October, so we'll see what new numbers look like.) I'm currently on .175 patches twice weekly, 150 spiro daily, 100 progesterone daily and 5 mg Finasteride for my enlarged prostate. (Just wish I'd paid more attention in my organic chem class in undergrad school. lol)

You are on the right track! I
Found out that estradiol can that two years or three to really get your breasts growing big that’s what happen with me! Keep higher level of estradiol unless you have a problem!, I have and now I am wearing a 42/DDD, after getting implants at 19 months, it Estradail starting my breasts at 24 months!.