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Hr positive Her2 AI and tamoxifen

Posted by sue417 @sue417, Feb 24 7:57am

Hi
Recently diagnosed with HR positive HER2 negative breast cancer discussion regarding going on a AI or tamoxifen. If I have had a TIA and I have osteopenia with 1 compression fracture, I do not feel safe going on any of these medications has anyone on here had similar health history and done these medications or what are your thoughts

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windyshores | @windyshores | Feb 24 9:26am

I has osteoporosis and did an aromatase inhibitor for 5 years (letrozole). My docs did not want to do Reclast due to afib which was, at the time a concern with Reclast but is no longer. My bone density went down quite a bit and I fractured during COVID before I could start Tymlos.

I have done 2 years Tymlos and two sets of injections of Evenity. The Tymlos brought my bone density up and it is now better than before my cancer and aromatase inhibitor treatment.

I did a Breast Cancer Index test after 5 years of letrozole that told me that although I am high risk (our risk goes up with hormonal cancers I was told) there is no benefit to extending an aromatase inhibitor. Others do 7 or 10 years.

If you do Reclast or Zometa, your bones will probably be fine but those meds do reduce the effectiveness of the bone builders like Forteo, Tymlos and Evenity though they will still be helpful. So it depends on how bad your bones are and how fast you want to increase BMD.

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1 reply
sue417 | @sue417 | Feb 24 10:19am
In reply to @windyshores "I has osteoporosis and did an aromatase inhibitor for 5 years (letrozole). My docs did not..." + (show)
@windyshores

I has osteoporosis and did an aromatase inhibitor for 5 years (letrozole). My docs did not want to do Reclast due to afib which was, at the time a concern with Reclast but is no longer. My bone density went down quite a bit and I fractured during COVID before I could start Tymlos.

I have done 2 years Tymlos and two sets of injections of Evenity. The Tymlos brought my bone density up and it is now better than before my cancer and aromatase inhibitor treatment.

I did a Breast Cancer Index test after 5 years of letrozole that told me that although I am high risk (our risk goes up with hormonal cancers I was told) there is no benefit to extending an aromatase inhibitor. Others do 7 or 10 years.

If you do Reclast or Zometa, your bones will probably be fine but those meds do reduce the effectiveness of the bone builders like Forteo, Tymlos and Evenity though they will still be helpful. So it depends on how bad your bones are and how fast you want to increase BMD.

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Hi
I have been doing zoldronic acid infusions for the past 2 years my third is this year in June and my bone density is come up quite a bit so I don't know what my oncologist is going to suggest he talks about tamoxifen 5mg but I don't know. Just had a 2nd surgery this past Tuesday sentinal node surgery only 1 lit up so he removed it. Waiting for results. Suppose to start radiation in March

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windyshores | @windyshores | Feb 24 10:37am

Oh if you have been on Reclast then maybe you can continue, I hope! I also hope the report on the sentinel node is reassuring. I am 9 years out...had grade 3, lymphovascular invasion, negative nodes. Good luck with it all!

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1 reply
sue417 | @sue417 | Feb 24 10:50am
In reply to @windyshores "Oh if you have been on Reclast then maybe you can continue, I hope! I also..." + (show)
@windyshores

Oh if you have been on Reclast then maybe you can continue, I hope! I also hope the report on the sentinel node is reassuring. I am 9 years out...had grade 3, lymphovascular invasion, negative nodes. Good luck with it all!

Jump to this post

Hi
What's lymphovascilar invasion? I had a lumpectomy it was dcis but when they did the pathology they found some invasive cancer so that's why they had to check my lymph glands. What kind of treatment did you have if you don't mind sharing

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1 reply
windyshores | @windyshores | Feb 24 6:17pm
In reply to @sue417 "Hi What's lymphovascilar invasion? I had a lumpectomy it was dcis but when they did the..." + (show)
@sue417

Hi
What's lymphovascilar invasion? I had a lumpectomy it was dcis but when they did the pathology they found some invasive cancer so that's why they had to check my lymph glands. What kind of treatment did you have if you don't mind sharing

Jump to this post

So you are probably fine and they are just being careful. With invasive cancer, however small, we all have those sentinel nodes checked.

I had a double mastectomy and 5 years aromatase inhibitor for ER+ PR+ HER2- mixed IDC, ILC, DCIS. Lymphovascular invasion for me meant cancer cells in the lymph vessels (others might have them in blood vessels).

Your node testing sounds just very precautionary.

If you are premenopausal tamoxifen is usually prescribed. Aromatase inibitors are for post-menopause.

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sue417 | @sue417 | Feb 24 6:55pm

Hi
My oncologist talked about tamoxifen because I've had a TIA I have a heart condition and I have osteopenia with a fracture compression in my spine. I am post menopausal but until all these results are back I won't really know what his plan is I have to have radiation in March unless something has changed

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