1. < Prostate Cancer

How many of our Fathers had BPH Prostate issues or Prostate Cancer?

Posted by jayhall @jayhall, Feb 20 3:25pm

My dad has been dead a number of years and the only thing that I know about his prostate issues were that he had BPH, high PSA numbers and had chronic long term prostatitis. I'm fairly certain that he had undiagnosed PC and didn't tell anyone. So here's my question to everyone here do you know if your father had any of these conditions?

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

heavyphil | @heavyphil | Feb 21 4:53pm
In reply to @jeffmarc "BRCA can’t actually skip generations, but getting no cancer with it sure can, the point I..." + (show)
@jeffmarc

BRCA can’t actually skip generations, but getting no cancer with it sure can, the point I think you were trying to make. If my mother didn’t have BRCA I could not get it. But her father sure had it when he died of pancreatic cancer in his 40s. The interesting thing is my mother‘s two sisters both got breast cancer, one of them died from it, And one of the daughters died of breast cancer, But my mother never had any cancers.

I am 49% Ashkenazi, The highest risk for BRCA, It is sort of weird since my father is Swiss Italian and my other half of DNA is all from there. The 49% that I have was after five generations of family in the same city, Which means four generations had to all be Ashkenazi for me to have that high a percentage.

Prromise, who does the free genetic test, Sent out a graph showing the personal hereditary information of people that took the test.. That’s how I knew what my percentages were. One benefit of taking the test is you’ll get that as well It did take them a couple years between taking the test and sending that information.

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Fascinating genetics as play, right? So if you have children, what are their odds, since you carry the defective (sorry!) gene - 50%?
My understanding of this is limited, but can BRCA1/2 mutations occur on both X and Y chromosomes or just one?
The literature talks about “in males, for example…” but males have both and women have XX.

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1 reply
jeffMar | @jeffmarc | Feb 21 6:51pm
In reply to @heavyphil "Fascinating genetics as play, right? So if you have children, what are their odds, since you..." + (show)
@heavyphil

Fascinating genetics as play, right? So if you have children, what are their odds, since you carry the defective (sorry!) gene - 50%?
My understanding of this is limited, but can BRCA1/2 mutations occur on both X and Y chromosomes or just one?
The literature talks about “in males, for example…” but males have both and women have XX.

Jump to this post

Yes 50% chance my children would get it and neither did.

If both parents have it there is a 75% chance of getting it from one parent and a 25% chance both will pass it on. If both pass it on, it is very unhealthy for the child.

It’s not tied to the X or Y chromosome it’s just something you have in your DNA.

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1 reply
bens1 | @bens1 | Feb 21 7:37pm
In reply to @jeffmarc "Those cancers are all related to having the BRCA genetic Defect. Have you had your hereditary..." + (show)
@jeffmarc

Those cancers are all related to having the BRCA genetic Defect. Have you had your hereditary genetics checked? The reason you want to do this is, if your children also have it they are warned about possible cancers.

If you live in the USA, you can get your Hereditary, genetic test for free from the below link. Don’t say that you want your doctor involved or they won’t send you the kit until they speak to your doctor. A geneticist will contact you about the results.

Prostatecancerpromise.org

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Thank you for the thought. I actually did have genetic tests and found no issues as I was concerned for my sons and daughter. All good in that direction.

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heavyphil | @heavyphil | Feb 22 5:59am
In reply to @jeffmarc "Yes 50% chance my children would get it and neither did. If both parents have it..." + (show)
@jeffmarc

Yes 50% chance my children would get it and neither did.

If both parents have it there is a 75% chance of getting it from one parent and a 25% chance both will pass it on. If both pass it on, it is very unhealthy for the child.

It’s not tied to the X or Y chromosome it’s just something you have in your DNA.

Jump to this post

Great news about your children - and your grandchildren. BRCA - Something else for them to look for on a prospective spouse’s list of assets and liabilities!😖

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trusam1 | @trusam1 | Feb 22 5:35pm

My father was diagnosed @ age 72, had radiation, died at 80 of metastatic PC. I was diagnosed @ 73, had surgery, and have had "undetectable" PSA since now turning 76. I have no details of my fathers diagnosis.

I hang out here assuming I may well need future treatment, but so far, the cancer has not affected my life.

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daveinflorida | @daveinflorida | Feb 23 12:13pm

My father was diagnosed in his mid-60s, which would have been early 90s. He had brachytherapy (or radioactive seeds as it was described to me at the time). He never mentioned it much after that, but lived 20 more years and died of Parkinson's so I guess the BT worked.

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gmr60 | @gmr60 | Feb 27 10:06am

I think my grandfather had PC, we are not 100% sure. My dad did have BPH, he also had a biopsy way back in 2005 that he says came back negative, he passed away at the age of 86 from Multiple Myeloma.

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mnj9092 | @mnj9092 | Feb 28 12:18pm

My Dad was diagnosed with Prostate cancer at 87 - spread to bones in pelvic area. Treated with radiation and then Zytiga. He's 92 now and PSA annually has been undetectable from the start. His quarterly infusion/hormone therapy seems to be working well. His doctor's have told him that the Prostate cancer is probably NOT what he will die from.
I was diagnosed at 62. Active surveillance until 64 and then determined best action was surgery to remove - done July 2024. First two PSA's less than .1.
Grandfathers on both side had PC. Cousin same age has me diagnosed recently and with surgery likely. The more I tell people about my journey the more people I meet that are dealing with PC.

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