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How long to does one stay on hormone therapy Orgovyx?
Psa < 0.1 after radiation n 6 months hormone therapy- psa was 47 n had gleason scores of 8 - 7 - 6 n cancer detected in seminal vesicles - what's the norm for continuing hormone therapy n why
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@jime51
Trimix is a combination of three different drug drugs for getting an erection, As you probably know.
You could speak to your urologist and ask to get just one of those drugs. You could eventually figure out which one is causing the problem if The first one didn’t work and you tried the second one. Maybe a bimix would work for you if You could eliminate the one that caused you problems.
I don’t think many oncologist are focusing on a cure for prostate cancer. They focus on a long-term remission, but there is a little chance of a cure. Because you’ve already had it extend beyond the prostate, there is no chance you will have a cure, But you could get long-term remission.
Staying on ADT alone can cause you to become castrate resistant, Which then has a median lifespan of two years (I’m six years past that point). You might ask to get on an ARSI like Zytiga or Darolutamide. That has been shown to delay the amount of time it takes to become castrate resistant.
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1 Reaction@jime51 I wonder about folks in our age group who may stop Orgovyx at 6 months, but T remains < 1 for a year or longer, is that equivalent to a year of ADT?
@mccannr
< 1 for a PSA is way too high if you’ve had surgery. It is recommended to have salvage radiation if it hits .2. If you’ve had radiation, then it can be fine if it keeps going down over time.
The amount of time you are on ADT depends on your Gleason score and your other problems found during your biopsy. If you have a Gleason 7 then 6 months is fine usually.
NCCN Recommends 18 months for a Gleason eight and 24 months for a Gleason nine. Other factors could change that.
I thought about that myself - if it takes a year for T to return cancer it's not being feed how is that any different than the drug itself. Not being critical my hormone drug is 4k a month
That I don't know, because a year of ADT might keep PSA low for more than a year following. Prostate cancer becomes castrate resistant at some point, and then something other than ADT has to be used. My Gleason score was only 7, normally indicating a short term use of ADT, but the PSMA PET scan showed cancer in two adjacent lymph nodes, so it's being treated as a more aggressive cancer with longer ADT recommended. I know patients who have refused ADT due to the side effects and are taking their chances regarding longevity in order not to interrupt quality of life, yet. We make the best choices we can with the information we have.
@jeffmarc It's my hope to switch from Orgovyx to Nubeqa at 13 months (end of a prescription) and use it alone for an additional six months. That'll give me 19, not their originally suggested 24 but ought to buy me a good amount of time before resuming treatment. I've got to get out from under these side effects. From the Orgovyx site, I'm going to try a "BRAT" (banana-rice-applesauce-toast) diet to see whether I can reduce or eliminate the current diarrhea I'm having (was up for episodes at 1:30, 3:30, 4:45, 5:30 and 7:30 A.M. today) and I'll ask for a Bimix that eliminates prostaglandin, which today's webinar speaker and online research indicate causes erection pain in some of us. Of course, it's the only chemical of the three that's covered by insurance.
@mccannr if your testosterone does not come back to even 50 for a year then it is equivalent to being on ADT for that year. That would be quite unusual. I was in a meeting today where one of the guys only had his testosterone go up to 70 after a year. He was not happy. Continue to have a number of side effects.