How long to maintain hormone therapy orgavulix

Your Gleason score was eight not 8 or 7 or 6. The highest number is the only one that counts. A Gleason, eight is very aggressive.

With a Gleason 8 you should be on ADT for 18 months according to the NCCN which sets the standards for prostate cancer treatment.

Having it spread to the seminal vesicles makes it much more aggressive, so you really should stick to the 18 months. I wonder if you had any more issues that you don’t realize are a problem like intraductal, cribriform, EPE or ECE.

If you want to find out how likely you are to have a recurrence soon, you can get a decipher test. You will see many people in this forum talking about having decipher testing and what the results were.

The drug is Orgovyx, one of the types of ADT.

Jeff, do you perhaps know what is recommended ADT time for adjutant or early salvage if PSA is undetectable ?
Thanks so much in advance : )

I had 3 leison - scores were - 4+4 - 3+3 n 3+4

Initially it was 3yrs on hormone therapy - not sure I can do 3yrs , I feel
like I'm wasting away

They want me to do 3yrs. Not sure I can do that long, I feel like I'm wasting away

This is really something you have to discuss with your doctor. I did a search on this since I have not heard specific numbers and it really is based on the extent of the prostate cancer case.

If you search Google for this

‘how much ADT time is suggested for somebody that has to have salvage radiation after a prostatectomy”

You will find a variety of answers based on the extent of the case. There is no simple answer.

Because your husband has had some serious issues I would definitely ask the doctor to give you an ARSI as well as ADT, If the doctor feels you should be on ADT for at least two years. The ARSI can extend the time before he becomes castrate resistant, and could greatly reduce that risk. The doctor may want this anyway because of the aggressive issues with his prostate cancer.

The doctor may say he should be on Zytiga, Something your husband could try, but it may be too much since he has a very active lifestyle. It can cause fatigue and blood pressure issues, But it is good to start with it if you can handle it. If Apalutamide or Enzalutamide are suggested you should definitely say that you want Darolutamide Since it has many fewer side effects.

Thanks Jeff 💗

It doesn’t matter what the lower Gleason scores were, the only one that counts is the eight.

The seven and six are not considered relevant because of the eight. You won’t find anybody saying they have more than one Gleason score, The medical community only considers the highest score as the one that is relevant.

An eight is very aggressive.

I’ve been on it nine years. If you want The best progression free survival you need to listen to what your doctor tells you.

You need to do a few things to be able to manage ADT (Orgovyx). For one you need to do a lot of exercises. I go to the track twice a day and run/jog a mile Each time. I also try to go to the gym three times a week and do weight training. This can offset the fatigue some people have.

I’ve never had the fatigue problem, but I’ve had others. I used to get a lot of hot flashes. I found ways around that.. When you are on ADT you will find your muscles deteriorate quickly. Your weakening stomach muscles will cause you to have a belly. Your other muscles will not keep up unless you exercise and do weight training.

Another thing you need to do is take bone straighteners because ADT weakens your bones. I took Fosamax pills once a week for six years and now I am on Zometa infusions every three months. A bone doctor at a recent prostate cancer conference said that everybody on ADT should be taking bone strengtheners. You should also be taking calcium and vitamin D. Calcium citrate is the preferred calcium and you should be taking 500 mg twice a day to keep your bone strength up. These are all things your doctor should’ve talked to you about. If not, you should talk to your doctor about it because these things are important.

If your doctor is not willing to do all these things, you need to get a second opinion at a center of excellence. You wanna make sure you are treated properly, especially since you have what appears to be a very aggressive cancer.

You should get a Dexa scan to find out how strong your bones are, They are going to get a lot weaker with ADT so you want to know how strong they are to start with. Ask your doctor about this.

Your prostate cancer case was apparently quite aggressive Or they would not have said you needed orgovyx (ADT) for three years.

Gleason eight only requires 18 months by the NCCN, that sets the standards for prostate cancer treatment. I would imagine your biopsy has shown that you have more aggressive problems withyour prostate cancer.

There must be more issues in your biopsy than you are aware of.