1. < Polymyalgia Rheumatica (PMR)

How long should a dose of Methylprednisolone last?

Posted by susanew @susanew, Jun 21 4:14am

I am finally back down to 1 mg. Methylprednisolone. I take my dose at 9 PM but by 8 pm the next day, I am achy. How long does a dose suppose to last? Does anyone feel the loss of effectiveness during the day? Am I dosing too low?

Interested in more discussions like this? Go to the Polymyalgia Rheumatica (PMR) Support Group.

Mentor
John, Volunteer Mentor | @johnbishop | Jun 21 7:27am

I'm guessing we are all a little different but here's what I found on your question while you wait for members with experience to respond.

"Official answer. After taking a dose of a Methylprednisolone tablet it should be out of your system after approximately 13 to 20 hours. Methylprednisolone tablets have an elimination half-life of approximately 2.5 hours to 3.5 hours. This is the time it takes for the drug levels in your plasma to reduce by half."
-- How long does methylprednisolone tablets stay in your system?: https://www.drugs.com/medical-answers/how-long-does-methylprednisolone-stay-in-your-177237/

REPLY
1 reply
susanew | @susanew | Jun 21 8:05am
In reply to @johnbishop "I'm guessing we are all a little different but here's what I found on your question..." + (show)
@johnbishop

I'm guessing we are all a little different but here's what I found on your question while you wait for members with experience to respond.

"Official answer. After taking a dose of a Methylprednisolone tablet it should be out of your system after approximately 13 to 20 hours. Methylprednisolone tablets have an elimination half-life of approximately 2.5 hours to 3.5 hours. This is the time it takes for the drug levels in your plasma to reduce by half."
-- How long does methylprednisolone tablets stay in your system?: https://www.drugs.com/medical-answers/how-long-does-methylprednisolone-stay-in-your-177237/

Jump to this post

Thank you. I never knew that. So maybe then I should take my dose much later or very, very early a.m. so that it remains in my system later the next day. Reason I take at night is so that I am not stiff upon waking in a.m. to feed and walk our dog.

REPLY
1 reply
Mentor
John, Volunteer Mentor | @johnbishop | Jun 21 8:12am
In reply to @susanew "Thank you. I never knew that. So maybe then I should take my dose much later..." + (show)
@susanew

Thank you. I never knew that. So maybe then I should take my dose much later or very, very early a.m. so that it remains in my system later the next day. Reason I take at night is so that I am not stiff upon waking in a.m. to feed and walk our dog.

Jump to this post

I've always been an early riser and when my PMR was active I took my morning prednisone dose before 8 am and it normally got me through until the next morning. There are others who've had good results splitting their dosage also.

REPLY
1 reply
susanew | @susanew | Jun 21 10:03am
In reply to @johnbishop "I've always been an early riser and when my PMR was active I took my morning..." + (show)
@johnbishop

I've always been an early riser and when my PMR was active I took my morning prednisone dose before 8 am and it normally got me through until the next morning. There are others who've had good results splitting their dosage also.

Jump to this post

I am up very early .. somewhere between 4 and 5 a.m. I cannot tell you how much I appreciate this article. It is very helpful.

REPLY
Please sign in or register to post a reply.