How fast does Orgovyx work to reduce PSA?

I started Orgovyx on 6/7 - PSA was 30.11. Blood test on 7/9 - PSA was 0.55. Next test 8/26 - PSA was 0.19. Hope this helps.

The PSA will go down immediately. You don’t say How high at the PSA was because that is a factor. As the previous person said within a 2-3 months it usually becomes undetectable. Undetectable is considered < .1.

Yes it does, thank you.

Thank you for your reply. Started on it yesterday, PSA of 6.3. Had prostatectomy in early June.

Seven weeks after my prostatectomy my PSA dropped to undetectable. Stayed that way for 3 1/2 years, Never did go on ADT until many years later. Usually, after a prostatectomy, the PSA drops to undetectable, unless there are metastasis somewhere.

It could be your PSA started out much higher before surgery so it’s taken time to come down.

I started Orgovyx July 11, 2025...had PSA 2 weeks ago and PSA was .5- it was over 50 to start..Gleason 8 -so what that tells you is your cancer is hormone driven and the ADT therapy is working. after that you will prob enter radiation therapy ( as I am about to start) which will further reduce and hopefully eradicate all cancer in prostate and surrounding tissues...

then you will prob stay on ADT therapy 1-2 yrs.

Note: the first month of ORGOVYX was very tough for me...you will experience hot flashes and night sweats and prob not feel great for the first month but dont give up, it gets better...this disease and treatment is a marathon, not a sprint...try to eat well, exercise and stay positive, as some of the longer term members here told me..this is a club no one wants to be in, but here we are..I am sure most all on this board will gladly talk to you privately if you need help..just message them and arrange ( including me..but I am only a few months ahead of you so I certainly dont know it all..;=) good LUCK !

Thanks for your motivational response. Yes the plan is to have radiation after some time on the Orgovyx. We heard the Orgovyx was a bit better than the older ADT drugs so we asked for it specifically. It is a journey indeed! Best wishes to all here, our fellow travelers.

in reference to "...then you will probably stay on ADT therapy 1-2 yrs." (Context G8 'High risk of mets)
https://dailynews.ascopubs.org/do/artificial-intelligence-derived-biomarker-may-help-reduce-adt-treatment-duration-some
Skinny on the attached:
Biomarker positives identified by MMAI showed some risk reduction benefit in long term use of hormone deprivation [LTADT/LADT] versus short term
[4-6 months] hormone deprivation [STADT/SADT]

NOTED limit: the data preceded the recent < 3 yr general use of PSMA PET/CT scans. IMHO a G8 or 9 pre 'scans' may harbor more extracapsular prostate extension (ECE) . The 'significant' but only modest difference was beneficial to biomarker positives with LADT. If scanned negatives might have been excluded
it begs the question if the 'significance' might have dropped to a margin of error range borrowing from social science.

My experience was in 6 weeks it went from .5 to undetectable...everyone is different it depends on the person being treated and how high there numbers are...it works....gl

Thanks for sharing!