How fast does Orgovyx work to reduce PSA?

I started Orgovyx on 6/7 - PSA was 30.11. Blood test on 7/9 - PSA was 0.55. Next test 8/26 - PSA was 0.19. Hope this helps.

The PSA will go down immediately. You don’t say How high at the PSA was because that is a factor. As the previous person said within a 2-3 months it usually becomes undetectable. Undetectable is considered < .1.

Yes it does, thank you.

Thank you for your reply. Started on it yesterday, PSA of 6.3. Had prostatectomy in early June.

Seven weeks after my prostatectomy my PSA dropped to undetectable. Stayed that way for 3 1/2 years, Never did go on ADT until many years later. Usually, after a prostatectomy, the PSA drops to undetectable, unless there are metastasis somewhere.

It could be your PSA started out much higher before surgery so it’s taken time to come down.

I started Orgovyx July 11, 2025...had PSA 2 weeks ago and PSA was .5- it was over 50 to start..Gleason 8 -so what that tells you is your cancer is hormone driven and the ADT therapy is working. after that you will prob enter radiation therapy ( as I am about to start) which will further reduce and hopefully eradicate all cancer in prostate and surrounding tissues...

then you will prob stay on ADT therapy 1-2 yrs.

Note: the first month of ORGOVYX was very tough for me...you will experience hot flashes and night sweats and prob not feel great for the first month but dont give up, it gets better...this disease and treatment is a marathon, not a sprint...try to eat well, exercise and stay positive, as some of the longer term members here told me..this is a club no one wants to be in, but here we are..I am sure most all on this board will gladly talk to you privately if you need help..just message them and arrange ( including me..but I am only a few months ahead of you so I certainly dont know it all..;=) good LUCK !

Thanks for your motivational response. Yes the plan is to have radiation after some time on the Orgovyx. We heard the Orgovyx was a bit better than the older ADT drugs so we asked for it specifically. It is a journey indeed! Best wishes to all here, our fellow travelers.