How early to begin infusions?

Posted by cjw1510 @cjw1510, Jun 25 6:30am

I have MCI and a PET scan identified amyloid plaque levels that are significant. My Centiloid measure was 32. My doctor has prescribed Aricept but advised against infusions because of the score being low and possible side effects. I have read that the earlier, the better.. Should I get a second opinion?

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Lisa Lucier, Moderator | @lisalucier | Jun 25 8:48am

Hi @cjw1510 - welcome to Mayo Clinic Connect.

Just for clarification, I believe you are speaking of intravenous (IV) monoclonal antibody infusions, such as lecanemab (Leqembi) or donanemab (Kisunla)?

cjw1510 | @cjw1510 | Jun 25 7:34pm

Yes, that is what I referred to.

midnightwalker | @midnightwalker | Jul 1 8:13am

I am on Aricept 5's and scheduled for my PET Scan next Friday. Been on Aricept for one year and my doctor says once I get on Leqembi, I should continue to take my Aricept. I'll let you know my PET Scan Centeloid score when I get it. Good luck. The Aricept 5's worked wonders on my memory issues but I didn't progress to the 10's as I felt they were too strong when I tried them.

cjw1510 | @cjw1510 | Jul 1 3:35pm

In reply to @midnightwalker "I am on Aricept 5's and scheduled for my PET Scan next Friday. Been on Aricept..." + (show)

@midnightwalker Thank you and all the best to you!

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