How did you reduce hot flashes from Orgovyx?

I wish I could remember (suffer from CRS), it was about 2 years ago, but, my RO offered me some drug to see if it would help minimize the flashes. I just can't remember what it was called. Ask at the office, I'm pretty sure they have something indicated for this. SSRIs come to mind like Venlafaxine and Paroxetine? Maybe?

I'm a little reluctant to take meds, I opted out of taking them so couldn't give you a report on how they worked.

Some tips for living with hot flushes (I've been on ADT since 2021):

1. Get a little desk fan, and have a bigger fan in your bedroom with a remote control on the bedside table.

2. Carry a small face towel in your backpack or briefcase when you're away from home.

3. Dress in layers so that you can de-layer during a hot flush.

4. Practice relaxation exercises, especially around the shoulders and upper back (relaxing can sometimes lessen or head off a hot flush for me).

5. Hold something cold against the inside of your wrist when you feel one starting.

6. Give it time. They were worst for me at the start, and have lessened over the years.

I started Orgovyx on Dec 19 and I have the same problem. My Radiologist recommended Black Cohosh. I ordered some but haven't received it yet. From what I've read on the internet it does not sound promising, but I will try it. My primary doctor wanted to prescribe Wellbutrin, but I'm not depressed, and I don't see any evidence that it works either, so I refused.
I wake up multiple times each night with my clothes and sheets wet. That makes me tired during the daytime, which makes it hard to keep exercising, which I know I should do.

I've been on Eligard for 3 weeks now. In the first two, I was symptom free; however, the past week I've had hot flashes every night. My MO said if they were bad, there are drugs that could be helpful, but I'll likely avoid more meds. My real annoyance is the fatigue. I have to make myself get up and do things. I'm certainly looking forward to the new and exacerbated side effects when I add Zytiga (and Prednisone) next week and in March, 9 weeks of IMRT!

I had terrible hot flashes for the first year after Starting Lupron. I would get them 10+ times a day, They would start off with a feeling of fatigue, followed by a hot flash that made The sweat pour down from my forehead into my eyes, My hair would be soaking wet. At night, I would wake up with the sheet under me, totally soaked.

My oncologist prescribed depo-provera To resolve the issue. It’s a birth control injection that is given every three months and while I was on Lupron, it pretty much stopped my hot flashes.

Then I want on Zytiga And the hot flashes came back.

I got introduced to a beta test for the Wave product From Embrlabs.com. It looks like a watch that you wear on the inside of your wrist, and it sends cold waves through your arm to stop the hot flashes (MIT invented it). They have a daytime mode, which gives you 5 to 10 minutes of cooling and a nighttime mode that lasts seven or eight hours. After using the nighttime mode, my nightly hot flashes stopped pretty much completely. During the day, as long as I hit the button on the wave Device quickly, when I felt the hot flash coming on, it would either stop it or greatly reduce its intensity. If you buy one they give you 30 days to send it back and they’ll give you a full refund.

There are other hormone solutions besides depo-provera, Ask your doctor.

Couple of different people have told me that eating tofu every day stopped their hot Flashes. I never tried it because I have other solutions, but you could try it

Two points:

1. Yes, it's tough.

2. Nevertheless, some of us "lifers" have found that it's possible not only to survive but to thrive despite being on ADT and ARSI indefinitely.

The most important thing is to rest when you need to, but be active when you can. It's not about exhausting yourself with intense workouts, but little things, like walking to the store instead of driving, getting off the subway a stop or two early, parking at the back of the mall parking lot, going for a 20 minute stroll a couple of times a day, and especially doing light resistance exercises (like weights or resistance bands) a few times a week to help maintain your bone and muscle mass. Light stretching every morning also helps me get going.

You might not be able to do it every day at first, and that's OK too, because your body also needs rest and recovery. But over the weeks and months, those little habits can really pay off.

Thank you! That was supportive & helpful! Good luck to you.

I tried both of those SSRIs. Venlafaxine produced sleepless nights. Paroxetine also affected sleep but not as badly. Eventually, the sleep deprivation was too much, and I tapered off of it. On the advice of my doctor at MSKCC, I tried acupuncture. It worked very well with no side effects. I went back occasionally for a “refresher,” but I was very happy with the results. Note that hot flashes can recur when you go off ADT.