High fasting glucose of 115 after 7 mos on Orgovyx

Increase in A1C is a common problem with ADT drugs like Orgovyx. Fasting blood sugar is frequently higher.

January2024 to November2024 on orgovyx, my fasting glucose increased from 90 to 103.

Similar changes to liver enzymes... still normal or borderline but moving in the wrong direction.

Stopped orgovyx in December. Hopefully blood tests next month will show improvement.

It is common, but you may want to talk to your medical oncologist to see if drug intervention might be necessary in the future. You still have 18 months to go on ADT but frequent blood testing (or urine strips for at home use) will show if any short term diabetes protocol might be necessary.

Thank you. I didn't realize there was a short term protocol available. My obvious concern was that once I started on a diabetes drug I would have to always take it even though my glucose returned to normal after stopping Orgovyx.

I forgot to mention that there is a solution to this problem. Change your diet. When you get prostate cancer, you need to stop eating red meat, you need to really cut back on sweets and increase the amount of vegetables you’re eating..

I was on ADT for eight years and my last A1C was 5.4. It hit 5.8 a couple of times before I really changed my diet.

I used to eat a sub sandwich for lunch every day. I now eat a huge salad. My wife must know 25 different ways of making chicken that are really good. I eat a lot of fish, Norwegian Salmon is pretty inexpensive at Trader Joe’s, tastes great and is good for you.

Change your diet and your A1C will reflect it. Something to consider.

I follow and exceed the guidelines in the book "Preventing Prostate cancer" by Benny Gavi MD
Clinical Assistant Professor of Medicine at Stanford University.
Foods to Avoid: Red and processed Meat, Eggs and Dairy
Foods to include: Vegetables and cruciferous vegetables
Tomatoes(Lycopene)
Soy
Green Tea
The book references Lot of studies. He says read the studies and MAKE YOUR OWN DECISIONS!

Great advice. I do eat as you recommend but have to up the volume.

Diet is the Number One thing to try first; however, some blood glucose changes are resistant and a short course of Metformin or a similar drug can be used - IF necessary!
People are taken off these drugs all the time once their blood glucose/A1C return to normal. Stopping Orgovyx will certainly help for sure.

Hi Ava, Yes, I agree that our decisions should be our own. Whoever Benny Gavi is, his advice is such boilerplate fluff that it could be used for everything from asthma to toenail fungus.
My friend had leukemia and thru holistic medicine and diet, sent it into remission. His key supplement was a pharmaceutically pure extract of Green Tea. But a blood test showed higher than usual PSA. Guess what?? Yup, prostate cancer!!
So maybe Green Tea caused it instead? Maybe his vegan diet did?
Not trying to bust your chops but so much of this supposed “research” is really a solution looking for a problem. Let’s blame this, let’s blame that and then see if we can find a correlation (innocent bystander) and call it causation (the culprit).
My mother smoked 3 packs of cigarettes for most of her life ( started at 8 yrs old - no lie!), ate a terrible diet even when she cooked wholesome food for our family, drank alcohol, ate all the foods Benny Gavi condemned and succumbed to Covid at age 98!!!
If you can fit her lifestyle into any research parameters that give her a life expectancy above the age of 45, please let me know.
Phil

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