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Help needed comparing CTX & P1NP results
Hello everyone! I have had one RECLAST plus one year TYMLOS. I just got my comparison scores back after one yearand I need help with the interpretation. I can’t remember who hear wanted to read my test result comparisons but here they are: CTX (bone transcription): start at 322 - one year later 643; P1NP (protein marker, stimulating bone growth) start at 49, one year later 102. When I looked these up, it was super confusing and it looked like it went in the wrong direction - but I might be the model of test results having ascended 100%, the NP canceled our appointment today because of an emergency and I can’t find anybody else at UCSD endocrinology to answer what I think is a very simple question. anyone knows if this is the case, I would love to hear it because I think it is encouraging. It’s not an easy road so to know that good results are possible would be helpful. I have changed a lot of my lifestyle because my bones ended up being soft in surgery (which the DEXA over the years did not pick ) and I want to improve as much as I can to maintain my degenerative conditions as I age, now 68 years old. Thank you!
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jozer, the bone markers aren't prescribed by many physicians. Some consider the assays unreliable, and consequently without signification.
Fosamax represses bone turnover which increases the risk of osteonecrosis of the jaw and atypical femur fracture. Given your previous hip fracture and the lack of gain in the left hip, you might consider your density numbers in that left femur while considering your options.
Stomach issues on the injectable bisphosphonates are less problematic because they avoid the alimentary canal. If your IBS is not autoimmune it might not have to be a consideration.
I'm partial to the bone building drug Forteo.
@gently the YouTube video you recommended is perfect! I’ve been watching it the last two mornings on the exercise bike and getting a lot out of it! It’s also over my head and I’m so impressed by your knowledge and experience and your ability to understand and digest it all! Since I am involved in my high school reunion leading the committee and getting a 19 piece show of my art up next week, my brain can only hold so much so I am taking away generalizations and Hope to watch the video over again so I can retain more of it in preparation for my meeting with the NP on May 29. What I am getting out of the information is that as horrible as the RECLAST was on the first go around and the TYMLOS with the malaise, I experienced the first two months because of my drug sensitivity and not being told to titrate up — in the end. They were the perfect prescription for me and the test results are proving that. I have questions but I’m going to wait till I really get a better handle on this. I’ll have my annual DEXA in a couple months and I think that will be the kicker on top of the blood tests! Thank you for your generosity and support in this process. This group at the Mayo Clinic forum online, I find, is so vital and helpful!