Have You Had A Delayed Injection Site Reaction to Tymlos?

Posted by CathyF31 @cathyf31, Apr 18 4:13pm

Has anyone else had a "delayed" skin reaction at your carefully rotating injection sites from Tymlos? After 24 injections, I have now started developing nickel-to-quarter sized welts that are taking 4+ days to fade. Surprised that this started 3 weeks after starting and was wondering uf rhis is cimmon among others? Any chance it's related to nearing the 30-day limit for the med to start degrading, as Tymlos warns about post-30 days? Just odd that it's started 3 weeks into treatment.

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Hi, I see no replies here.
I’ve been injecting for 2 months now and just started seeing the site reaction like an erythema . What did you end up doing or find out if it’s ok to keep injecting?

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I’ve been injecting for 2.5 months and had no injection site reaction. Do you pinch/gather skin/fat to do the injection? If so, maybe stop doing that. I had seen that as being part of the Tymlos demo video, but I am thin and thought that would only serve to bruise me. I just lie flat and inject without gathering any part of my skin/fat. Inject straight (45 degree angle to skin), so it goes as deep as the short needle can. And of course rotate your injection sites so you’re not building scar tissue. I hope this helps.

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Profile picture for sami51929 @sami51929

Hi, I see no replies here.
I’ve been injecting for 2 months now and just started seeing the site reaction like an erythema . What did you end up doing or find out if it’s ok to keep injecting?

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@sami51929 Hi. My welts and hives continued strongly for about 3 months (taking 5-8 days to fade...so typically, 5 to 8 angry hives/welts on my belly at any given time), then they started to lessen. I still get raised areas (1 or 2), but they typically are less severe and they fade within a day or two. I'll apply a little Benedryl Cream, when they surface more angrily than usual....and sometimes will hold an ice cube (wrapped in a Kleenex) against the spot. My immune system decided to stop responding so terribly, starting around that 3-month mark. My provider and each specialty pharmacists wanted me to discontinue the medicine, but it was my last option, before having to default to Reclast, so I begged and pleaded to stay on. I can only tolerate the 1/2-dose (40 mcg), due ro other side effects. So, for me, my body adjusted over time, it still takes my body over 24 hours to react at the injection site, before it starts to flare. Trying to come up with specifics that may cause some injections to flare worse than others, but I have not been able to identify a pattern.

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Profile picture for CathyF31 @cathyf31

@sami51929 Hi. My welts and hives continued strongly for about 3 months (taking 5-8 days to fade...so typically, 5 to 8 angry hives/welts on my belly at any given time), then they started to lessen. I still get raised areas (1 or 2), but they typically are less severe and they fade within a day or two. I'll apply a little Benedryl Cream, when they surface more angrily than usual....and sometimes will hold an ice cube (wrapped in a Kleenex) against the spot. My immune system decided to stop responding so terribly, starting around that 3-month mark. My provider and each specialty pharmacists wanted me to discontinue the medicine, but it was my last option, before having to default to Reclast, so I begged and pleaded to stay on. I can only tolerate the 1/2-dose (40 mcg), due ro other side effects. So, for me, my body adjusted over time, it still takes my body over 24 hours to react at the injection site, before it starts to flare. Trying to come up with specifics that may cause some injections to flare worse than others, but I have not been able to identify a pattern.

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@cathyf31 Wow, you are tough! That is very interesting and inspirational that hanging in there with worked for you and the hives lessened. Thanks for sharing.

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