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Has cabozantinib (Cabometyx) stopped working for anyone?
Been taking Cabozantinib for a year now, and have heard that it tends to lose effectiveness on cancer progression over time.
Take it for stage IV pancreatic insulinoma with liver metastasis. The last MRI looked good, but am having more low glucose alerts than previously. Wondered if anyone else had been taking the drug and what the next treatment would be if they had to stop?
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Cabozantinib can work for a long time, but like many cancer treatments it may eventually lose effectiveness. The increase in low glucose alerts could be a sign that your insulinoma is becoming more active again, so it’s definitely worth discussing with your oncologist.
Yes, thanks, I sent notes to both my oncologist and endocrinologist and received replies from their staff. The upshot is that scans and tests look good, try more frequent meals, cornstarch before bed and so on. Dexamethasone was also mentioned.
One reason I was concerned was that I also had early symptoms in March 2025 but didn’t worry about it because the CT scans were so good. I ended up back in the hospital in April for surgery and later started cabometyx. (PET scan later showed increased activity which the CT scan missed).
Another concern is that the oncologist I’ve seen for the last two years is leaving for another hospital. I don’t know who will replace him or when I will be seeing them.