Has anyone had these atypical features with their Metastatic PC???
I am 65 years old and was diagnosed with metastatic prostate cancer in January 2025 with PSA = 70; prostate biopsy showing fairly low volume Gleason 4+3 [95% pattern 4] involving 8/16 cores, 9% tissue involvement
- Presented with weight loss, early satiety, night sweats and CT scan showing multiple retroperitoneal / iliac lymph node metastases. CT chest shows mediastinal lymphadenopathy.
- Interestingly, bone scans in Jan and Aug 2025 are negative for metastasis???
- Most recent CT pelvis/ abdomen and chest show no pelvic nodes (I had prostate radiation in March 2025) but there is a new adrenal nodule (presumably a metastasis) as well as peritoneal nodules suggestive of carcinosis - I believe both of these areas are atypical locations for prostate cancer metastases???
- Finally despite successful doublet therapy with Orgovyx (ADT) and Abiraterone/ Prednisone (testosterone levels are undetectable), my lowest PSA was 7 in May 2025 and more recently has increased to 30! In other words I am hormone resistant from the outset???
QUESTION: is this just an aggressive form of Prostate Cancer or could it be lymphoma? Not sure if I am continuing to have night sweats or are these hot flashes from ADT?
FYI - I have not had a PSMA-PET scan
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Thanks for your note. You are right - this is a challenging mind game. Best of luck.