Has anyone had secondary cancers following Multiple Myeloma diagnosis?

Posted by roselouise @roselouise, May 30 4:07pm

I was diagnosed 4 years ago with MM. two years later I had melanoma on the bottom of my foot. In 2025 I have been diagnosed with invasive ductal carcinoma of my right breast. I am of the opinion that it is from my MM and treatment which has been Dex, Velcade Darzalex and revlimid.

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treehouse5437 | @treehouse5437 | Jun 2 8:56am

Diagnosed MM Jan '25 started treatment Feb '25. Pet Scan after Bone Marrow Biopsy and before starting treatment.

roselouise | @roselouise | Jun 2 2:46pm

In reply to @treehouse5437 "Diagnosed MM Jan '25 started treatment Feb '25. Pet Scan after Bone Marrow Biopsy and before..." + (show)

Thank you.

tally9004 | @tally9004 | Jun 3 7:25am

Hi,

I have been taking Revlimid and I am just starting my 4th cycle, and I think about getting secondary cancers from the treatment. I discussed it with my doctor and given that I have high-risk myeloma, I am willing to take the risk. But, I don't like the idea of getting another cancer! This drug sure has the potential for terrible side effects.

roselouise | @roselouise | Jun 3 11:23am

Revlimid has been found to cause melanoma. As soon as I was diagnosed with melanoma, my hematologist took me off of Revlimid. It is a risk of taking Revlimid. Not everyone will react the way I did. I, too, am high risk MM.

msh466 | @msh466 | Jun 4 8:06am

I currently have smoldering myeloma (I think). Have two bumps growing on my right leg. Growing not sure about that but showing. Get an Ultra sound that shows hypoechotic lesions either one of the two bumps showing blood flow on ultrasound I did not know about extraosseous myeloma. Which is a progression with worse outcomes. I have yet to get biopsies of these lumps. But it brings it closer to home. This smoldering myeloma is a powder keg that can go off in any direction at any time. Myeloma in general is a terrible cancer. I’m hoping for best.

Ginger, Volunteer Mentor | @gingerw | Jun 4 6:53pm

I guess for me it is a "which came first, the chicken or the egg" scenario. I moved from MGUS to SMM to active MM in 2019, and have been on treatment since Aug 2021. My skin cancer journey started back in the mid-80s, and had melanoma surgery Dec 2008. Since then, several cases of basal cell and squamous.

Like others here I have been on low dose Revlimid, dex, and Ninlaro. Now waiting for biopsy results from right bicep that is acting suspiciously like my amelanotic [non-colored] melanoma did.
Ginger

roselouise | @roselouise | Jun 4 11:42pm

Very interesting. Thanks for sharing this information.

hsminc | @hsminc | Jun 6 11:37am

You might also sign up for the SmartPatients group. I have seen input from a number of patients that developed secondary cancers. The more information the better is my motto and patients can be a fantastic source of good information.
Good luck and best wishes.

roselouise | @roselouise | Jun 6 12:23pm

Thanks for the suggestion. I agree to get the most information a person can get.

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