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Has anyone experienced profound hypotension with exercise while on ADT

Posted by mccannr @mccannr, 17 hours ago

About 5 months into ADT (Orgovyx) I began to feel light headed during exercise, it was accompanied by a sensation bright lights and colors. I was able to take my blood pressure at the local Y and it was consistently 80/50. I was well hydrated, my normal BP is a little high (140/80). I think it might be autonomic dysregulation from low T. Anyone else?

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jeff Marchi | @jeffmarc | 16 hours ago

Low blood pressure directly affects your Feeling lightheaded with or without exercises.

Yes, low testosterone can be associated with autonomic dysregulation, particularly an unfavorable shift in cardiovascular autonomic tone in men, and low testosterone has been linked to a higher risk of autonomic dysfunction, though the exact nature of the relationship is complex and multifactorial. Studies suggest a bidirectional link where low testosterone and autonomic dysfunction can influence each other, often in the context of conditions like metabolic syndrome.

Here is an article that discusses the above in more detail.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4825316/#:~:text=Previous%20studies%20have%20reported%20that,risk%20factor%20for%20cardiovascular%20events.

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mccannr | @mccannr | 14 hours ago
In reply to @jeffmarc "Low blood pressure directly affects your Feeling lightheaded with or without exercises. Yes, low testosterone can..." + (show)
Profile picture for jeff Marchi @jeffmarc

Low blood pressure directly affects your Feeling lightheaded with or without exercises.

Yes, low testosterone can be associated with autonomic dysregulation, particularly an unfavorable shift in cardiovascular autonomic tone in men, and low testosterone has been linked to a higher risk of autonomic dysfunction, though the exact nature of the relationship is complex and multifactorial. Studies suggest a bidirectional link where low testosterone and autonomic dysfunction can influence each other, often in the context of conditions like metabolic syndrome.

Here is an article that discusses the above in more detail.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4825316/#:~:text=Previous%20studies%20have%20reported%20that,risk%20factor%20for%20cardiovascular%20events.

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Thanks. Those studies discuss low testosterone, but not the essentially zero testosterone of ADT. So far I have no evidence of glucose intolerance or metabolic syndrome. I wonder if anyone has looked at CAN in ADT patients. Looks like the mechanism is too complex to suggest an intervention on my part.

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jeff Marchi | @jeffmarc | 12 hours ago
In reply to @mccannr "Thanks. Those studies discuss low testosterone, but not the essentially zero testosterone of ADT. So far..." + (show)
Profile picture for mccannr @mccannr

Thanks. Those studies discuss low testosterone, but not the essentially zero testosterone of ADT. So far I have no evidence of glucose intolerance or metabolic syndrome. I wonder if anyone has looked at CAN in ADT patients. Looks like the mechanism is too complex to suggest an intervention on my part.

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ADT doesn’t drop your testosterone down to zero. The reason they give people Zytiga is because ADT only gets it down so low and Zytiga gets it down below five.

After being on ADT for six years, my testosterone never got much below 5, except when I was on Zytiga.

Are you sure yours is getting down to zero?

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asolidrock | @asolidrock | 10 hours ago

What's strange with me before chemo I was on BP medications and now I have to be careful for my BP to be too low. Don't know if this helps or not.

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