Has anyone been treated with Panitumumab for cancer?

Posted by mscoyote @mscoyote, Oct 24, 2019

I am getting the side-effects of acne and am excited that panitumumab may be working, but how effective is it? Chemo has stopped working on me and I don’t know what this drug can do.

My previous treatment of oxaliplatin, bevacizumab and flourocil for stage 4 CRC has stopped working and now I am being given panitumumab alone. My previous oncologist said I should not be taking antioxidents with bevacizumab, but this one (a few of them alternate at my hospital), didn't seem to know anything about whether antioxidents or cannabinoids would interfere with panitumumab. Does anyone know anything about this?

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Anyone ever been on panitumumab? I have the basic I do sheet on it, but can'take seem to find out anywhere about diet. Wondering if any mentors are familiar with it?

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@mscoyote Hi and welcome again! The drug that you are now taking is called a monoclonal antibody (the ‘mab’ at the end signifies this). They are somewhat new-ish and work differently. I take rituximab for my autoimmune disease and it must work because I’ve been doing so much better. Are you scheduled for any scans soon? What did the doctor tell you about the drug?

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They explained the side effects, but when I was on bevacizumab along with some chemo drugs the oncologist I was seeing at that time told me to avoid foods high in antioxidants as they made the bevacizumab less effective. This oncologist didn't know whether antioxidants, vitamins or herbals interfere with panitumumab or not and I'm not sure where to turn.

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Benefits of antioxidants. https://newsnetwork.mayoclinic.org/discussion/a-grocery-bag-of-beneficial-antioxidants/. You might look here @mscoyote and see if it takes you to other sites. Try looking up the drug by name or get the manufacturers name and call them. Let me know what you find out, please

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@mscoyote

My previous treatment of oxaliplatin, bevacizumab and flourocil for stage 4 CRC has stopped working and now I am being given panitumumab alone. My previous oncologist said I should not be taking antioxidents with bevacizumab, but this one (a few of them alternate at my hospital), didn't seem to know anything about whether antioxidents or cannabinoids would interfere with panitumumab. Does anyone know anything about this?

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This might answer your question @mscoyote Info on panitumumab and supplements. https://www.ncbi.nlm.nih.gov/pubmed/30661095. I would also strongly suggest that your talk with your oncologist about the specific supplements you want to take. I hope this will help some. Let me know!

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@mscoyote

Anyone ever been on panitumumab? I have the basic I do sheet on it, but can'take seem to find out anywhere about diet. Wondering if any mentors are familiar with it?

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@mscoyote I can’t find any information on diet and panitumumab so I’m going to ask @johnbishop (the internet guru!) for his help

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Thanks so much, becsbuddy!

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@becsbuddy

@mscoyote I can’t find any information on diet and panitumumab so I’m going to ask @johnbishop (the internet guru!) for his help

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@mscoyote and @becsbuddy I'm not able to find any information on a specific diet when on panitumumab. I did find some self care tips on the following site that mentioned good nutrition and limit alcohol plus a few other things.
http://chemocare.com/chemotherapy/drug-info/Vectibix.aspx

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@becsbuddy

This might answer your question @mscoyote Info on panitumumab and supplements. https://www.ncbi.nlm.nih.gov/pubmed/30661095. I would also strongly suggest that your talk with your oncologist about the specific supplements you want to take. I hope this will help some. Let me know!

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Yes, I'm on a magnesium supplement now. Today my oncology nurse referred me to the pharmacist, so I hope to find out more later today. As I mentioned earlier, on bevacizumab, I was told to AVOID high levels of anti-oxidents as they interfered with the drug. I don't want to decrease the effectiveness of panitumumab, which is why I asked.

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@johnbishop

@mscoyote and @becsbuddy I'm not able to find any information on a specific diet when on panitumumab. I did find some self care tips on the following site that mentioned good nutrition and limit alcohol plus a few other things.
http://chemocare.com/chemotherapy/drug-info/Vectibix.aspx

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Thanks, johnbishop. I found the article interesting, but I guess my fear is that some antioxidants, vitamins, etc. or else large amounts of them may block the receptors on cancer cells and restrict the admission of the cancer drug into the cell (as has been suggested by some of my health care team). Then again, other reputable sites such as the mayo grocery bag site recommended above seem to indicate that antioxidants are very effective in preventing cancer growth. My assumption was that it depends on the drug, but there doesn't seem to be much information about panitumumab, so I'm not sure whether to curb my intake of antioxidants and vitamin C and green tea etc. or indulge.

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@mscoyote

Thanks, johnbishop. I found the article interesting, but I guess my fear is that some antioxidants, vitamins, etc. or else large amounts of them may block the receptors on cancer cells and restrict the admission of the cancer drug into the cell (as has been suggested by some of my health care team). Then again, other reputable sites such as the mayo grocery bag site recommended above seem to indicate that antioxidants are very effective in preventing cancer growth. My assumption was that it depends on the drug, but there doesn't seem to be much information about panitumumab, so I'm not sure whether to curb my intake of antioxidants and vitamin C and green tea etc. or indulge.

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Hi @mscoyote I’d be interested in hearing what you learned from the pharmacist. What did they tell you about possible interactions with antioxidants, vitamin C, green tea etc. Or did they say that some foods or supplement could support the therapy? Have you also considered consulting a nutritionist who specialized in oncology?

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hi @coleenyoung, One pharmacist told me he couldn't find much about any foods or supplements interacting with the drug but advised me to still refrain from high doses of antioxidants in food and teas. I never heard back from the hospital pharmacy, but will try again. The oncology nutritionists I found on online didn't have anything about panitumumab. Still looking.

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Hi @mscoyote,

I’m tagging @lah @brenz @rayleemorris and @davy80 who has written about Vectibix (panitumumab) in this discussion:
https://connect.mayoclinic.org/discussion/vectibix/

Of course, here’s information from Mayo Clinic https://www.mayoclinic.org/drugs-supplements/panitumumab-intravenous-route/precautions/drg-20069235 and I’d sincerely encourage you to go through these pages published by EMA – European Medicines Agency; it has a wealth of information about Panitumumab
https://www.ema.europa.eu/en/documents/product-information/vectibix-epar-product-information_en.pdf

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thanks so much for the EMA info. I can't understand all of it, but what I did understand was very interesting and it does seem that we don't have to worry about reactions with food, at least as far as they know at this time. Fingers crossed.

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