The doctors usually want to do it When the PSA hits .2. The fact that yours has not hit .2 could allow you to wait. I would want monthly blood test to see what’s going on. If you don’t treat it soon after .2 there are problems, Though some doctor say, wait until you can see the metastasis and zap them.
You don’t mention how quickly your PSA went from .04 to .1. Some people get six month tests and that makes it hard to evaluate. What’s going on when it starts to rise.. They want to know the doubling rate and the numbers you provided don’t really give enough information for timing.
ASCO, which sets the standards for prostate cancer treatment has posted the following.
From Ascopubs about what PSA to do salvage radiation.
≤0.2 ng/mL: Starting at this level maximizes disease control and long-term survival. Patients treated at PSA < 0.2 ng/mL achieve higher rates of undetectable post-SRT PSA (56-70%) and improved 5-year progression-free survival (62.7-75%). Delaying SRT beyond PSA ≥0.25 ng/mL increases mortality risk by ~50%.
0.2–0.5 ng/mL: Still effective, particularly for patients with low-risk features (e.g., Gleason ≤7, slow PSA doubling time). The Journal of Clinical Oncology recommends SRT before PSA exceeds 0.25 ng/mL to preserve curative potential.
0.5–1.0 ng/mL: Salvage radiation remains beneficial but may require combining with androgen deprivation therapy (ADT) for higher-risk cases.
Hi Jeff,
This is really interesting information, thanks for sharing it. Can you provide a reference, so that I can find the actual paper? I am only 6 weeks post RARP and have not had a PSA, but I like to be prepared.....hopefully without obsessing. 🙂
Mark
Hi Jeff,
This is really interesting information, thanks for sharing it. Can you provide a reference, so that I can find the actual paper? I am only 6 weeks post RARP and have not had a PSA, but I like to be prepared.....hopefully without obsessing. 🙂
Mark
Even with a PSA of 0.10, they’ll need to know where the recurrence is before trying radiation.
What were the results of your recent PSMA PET scan?
This may help...
https://www.urotoday.com/conference-highlights/sociedad-colombiana-de-urologia-scu-colombia-2025/162647-scu-2025-evaluation-and-management-of-biochemical-recurrence-in-prostate-cancer.html?utm_source=newsletter_14548&utm_medium=email&utm_campaign=prostate-cancer-daily
Hi Jeff,
This is really interesting information, thanks for sharing it. Can you provide a reference, so that I can find the actual paper? I am only 6 weeks post RARP and have not had a PSA, but I like to be prepared.....hopefully without obsessing. 🙂
Mark
This article seems to cover it though not exactly the same as the original article I saw.
https://ascopost.com/news/march-2023/psa-level-at-time-of-salvage-radiation-therapy-after-radical-prostatectomy-and-risk-of-all-cause-mortality/
For sometime there, I didn’t actually save the link to the article, I do that now.