Genetic tests available for breast cancer detection

Posted by BRCA @biohazard12, Mon, Oct 21 3:19am

Would like to know all the different DNA tests available for testing the susceptibility to Breast cancer. Required for an individual (daughter 33 years of age) whose mother was a cancer patient with the following (FISH Her-2/neu test is borderline, ER, PR positive). Later on detected with stage 4 (multiple sclerotic lesions in the liver). Background: The cancer patient's sister and mother are healthy individuals and are presently over 50 and 75 years of age respectively.
I want to get the individual tested for

I was seen by a geneticist for testing. I believe there are 26 variants they looked at two years ago for breast cancer. The geneticist will get family history and will know what tests to order

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I agree with betsyk, see a geneticist. Right after I was diagnosed with breast cancer, I saw a geneticist at Mayo Rochester. She was excellent explaining what tests are available, and pros and cons of testing. I was lucky that insurance covered the testing. I had a sister who had breast cancer in her 40s, she had testing 15 years ago and showed no genetic connection. My testing last year included more tests then was available 15 years ago, but showed no genetic link. The testing included more then just breast cancer. I was glad to results so could inform my sisters and nieces. I have no children myself.

If insurance covers or can afford, I recommend testing for peace of mind.

Laurie

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Last year I was diagnosed with breast cancer for the second time. The first time was 2007. I had genetic testing done in September. The test I had was from Ambry genetics which tested for 17 genetic mutations. I have CHEK2 mutation and because that showed up for me, my daughter was tested and she also has it.

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I was referred to a genetic counselor after my breast cancer diagnosis and was tested. I am BRCA2 positive and found out my daughter is also. You can find good information at facingourrisk.org about the genetic risks, research and gain a better understanding of hereditary cancer.

Liked by elizm

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@sandyjr

Last year I was diagnosed with breast cancer for the second time. The first time was 2007. I had genetic testing done in September. The test I had was from Ambry genetics which tested for 17 genetic mutations. I have CHEK2 mutation and because that showed up for me, my daughter was tested and she also has it.

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I had breast cancer in 2007 as well. I thought after the 10 year mark everything was clear. I am looking at genetic testing currently with a genetic counselor. Is there a difference between sending out blood or a cheek swab?

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@leeannaw

I had breast cancer in 2007 as well. I thought after the 10 year mark everything was clear. I am looking at genetic testing currently with a genetic counselor. Is there a difference between sending out blood or a cheek swab?

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I don’t know the difference but am guessing blood test may be more accurate as that is what the geneticist performed.

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I just had the genetic testing done and they did the saliva test on me. They said both tests are very accurate. One was no better than the other. I told them that I would rather have that as I have had bilateral breast cancer with sentinel node removal and was being cautious about blood draws.

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BTW my genetic test showed I have the CHEK2 mutation which is rare.

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I wish I would have done the testing prior to treatments. I was diagnosed with triple negative in ‘15. Had a lumpectomy as it was found early and small, then chemo and radiation. I was 65 but wondered why it turned up so late in life. So I saw the genetic counselor and we decided to look at my relatives and there was a number of my generation that had the secondary cancers of the BRCA cancers. I agreed to be tested and I am BRCA2. So I decided I needed to do more to keep the cancer away. Fallopian tubes and ovaries removed in ‘17, bilateral mastectomy and reconstruction in ‘18. Now having all this behind me, I feel great and very pleased with all my care at Mayo Rochester.

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@syska

I wish I would have done the testing prior to treatments. I was diagnosed with triple negative in ‘15. Had a lumpectomy as it was found early and small, then chemo and radiation. I was 65 but wondered why it turned up so late in life. So I saw the genetic counselor and we decided to look at my relatives and there was a number of my generation that had the secondary cancers of the BRCA cancers. I agreed to be tested and I am BRCA2. So I decided I needed to do more to keep the cancer away. Fallopian tubes and ovaries removed in ‘17, bilateral mastectomy and reconstruction in ‘18. Now having all this behind me, I feel great and very pleased with all my care at Mayo Rochester.

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Wow! You have been through a lot! Glad you have your surgeries behind you!

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@syska

I wish I would have done the testing prior to treatments. I was diagnosed with triple negative in ‘15. Had a lumpectomy as it was found early and small, then chemo and radiation. I was 65 but wondered why it turned up so late in life. So I saw the genetic counselor and we decided to look at my relatives and there was a number of my generation that had the secondary cancers of the BRCA cancers. I agreed to be tested and I am BRCA2. So I decided I needed to do more to keep the cancer away. Fallopian tubes and ovaries removed in ‘17, bilateral mastectomy and reconstruction in ‘18. Now having all this behind me, I feel great and very pleased with all my care at Mayo Rochester.

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Congratulations on being so proactive in order to prevent more cancer, @syska. I'm glad that the information from your genetic testing helped you. Would you recommend genetic testing to others in the early stages of breast cancer treatment?

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@hopeful33250

Congratulations on being so proactive in order to prevent more cancer, @syska. I'm glad that the information from your genetic testing helped you. Would you recommend genetic testing to others in the early stages of breast cancer treatment?

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Yes I would especially if they are triple negative. In the last few years so many new discoveries have been found to help with the treatments.

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Five years ago I was diagnosed triple negative in the left breast and ER+ in the right breast. Had genetic testing (sister had ER+ 30 years ago). Positive for the BRCA 1 and BRCA 2 gene mutation. Had chemo (AC and taxol), bilateral mastectomy and hysterectomy. Yes, went through the 5 years of arimidex with joint and bone pain. My daughter tested positive for the BRCA 1 mutation. This summer she was diagnosed with triple negative. She went through chemo and had bilateral mastectomy 3 days ago. She is only 31 and does not have children (23 eggs retrieved before treatment!). The doctors recommend hysterectomy by 37. Her cancer was caught early because of vigilant screening due to BRCA 1 results. The genetic testing is a very personal decision, but was the right choice for us.

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@patsydanley

Five years ago I was diagnosed triple negative in the left breast and ER+ in the right breast. Had genetic testing (sister had ER+ 30 years ago). Positive for the BRCA 1 and BRCA 2 gene mutation. Had chemo (AC and taxol), bilateral mastectomy and hysterectomy. Yes, went through the 5 years of arimidex with joint and bone pain. My daughter tested positive for the BRCA 1 mutation. This summer she was diagnosed with triple negative. She went through chemo and had bilateral mastectomy 3 days ago. She is only 31 and does not have children (23 eggs retrieved before treatment!). The doctors recommend hysterectomy by 37. Her cancer was caught early because of vigilant screening due to BRCA 1 results. The genetic testing is a very personal decision, but was the right choice for us.

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Hi @patsydanley ,
You and your daughter have provided another great example of using genetic testing in a manner that resulted in early detection for your daughter's breast cancer and personal planning for the future.

Was genetic testing suggested by your physician or was this your own decision?

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@hopeful33250

Hi @patsydanley ,
You and your daughter have provided another great example of using genetic testing in a manner that resulted in early detection for your daughter's breast cancer and personal planning for the future.

Was genetic testing suggested by your physician or was this your own decision?

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My oncologist recommended it given our family history (my grandmother had ovarian cancer 50 years before). When my sister had cancer, I began having mammograms at 35. I was diagnosed at age 60.

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