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Genetic testing...does anyone have the CHEK2 gene mutation?
I have had bilateral breast cancer. According to my genetic test, I do not have the BRAC1 or BRAC2 mutation...I have the very rare CHEK 2 mutation. Has anyone had this mutation? If so, what was your plan of action?
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I have the Chek2 gene and 2 of my 3 adult children recently tested positive for it. They are now being followed closely by their physicians who are familiar with this nasty gene.
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2 ReactionsMy daughter has the CHEK2 mutation. She found out when she was enrolled in a study.
I had breast cancer 30 years ago. There is no history of any cancer in my family.
I will request a genetic study myself- I have another daughter and a son.
My daughter with the CHEK2 has been followed with mammogram, ultrasound and MRI after suspicious findings. So far, so good.
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1 ReactionType Google Scholar onto your Google search bar. It will take you to 100's of articles about Chek2.
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2 ReactionsI have Chek 2 and have been treated for prostate and breast cancer. I see my internist and Mayo oncologist and proton radiation oncologist each twice each year. So far I am doing well but hate tamoxifen 🤢!
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1 ReactionI have the Chek2 gene and have been treated with proton radiation for prostate CA and last year had left mastectomy, 3 positive nodes and 16 proton radiation tx at Mayo Clinic in MN. So far ok?!.
Yes. My husband had me set up a Google Alert for anastrozole (which is how I found all of you!) and also an alert for BRIP1 where I have a mutation that is a variant of unknown significance (VUS) meaning they don’t know for sure if it’s benign or pathogenic for ovarian cancer. They are not sure if it’s related to breast cancer either, but more likely ovarian. At my age I would be delighted to take it all out because I don’t even want to think about it but since it’s unknown, I can’t be proactive.
I have CHEK2 and have had thyroid cancer.
No I did not have breast radiation yet because I think someone at MDAnderson needs to take a look at all of the information. I did have radiation RAI131 for the thyroid cancer. I feel like this radiation tipped the scales and that is why I am seeing the breast cancer. If I had never had that I would not be as concerned about doing more radiation. It also seems like some people with this Gene saw a second cancer within 10 years in the other breast. Even without this gene it seems that scatter radiation can do that. I just do not want to get 5 years down the road and be told I have another more serious breast cancer. Right now I have had two very treatable cancers. The next time I might not be so lucky.
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1 Reaction@sandyjr, I've been using Google and internet searches. But you're right. Most of the information comes from research studies and journals. There's not much info in layman's language unfortunately. The link in my post above is pretty comprehensive and not too hard to understand, not easy, but not too hard.
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1 ReactionThis is interesting. Where are you finding your information on CHEK2? I have tried to find out more about the mutation but have not been very successful. I was not told anything about radiation causing cancer if a person has this mutation. My mutation is p.R137*. I sure would like to find more information about it. The genetic counselor did not specify anything other than it increases my chance of getting breast and colon cancer. How do I find understandable information about this.