Anyone on Gemcitabine with Abraxane? How long? Effective?

That’s wonderful news gracect! That’s the longest time I’ve heard anyone being on GA. I was on 5FU in early 2023, and then when it metastasized when I came off it, I was switched to GAC chemo early this year so going on 11 months now. May I ask which mutations you have? Mutations type can drive the treatment response. Mine are KRASD12, TP53, and ATM. Thank you for your post as it will help others.

I am in the same situation as you are to a tee! 5FU did not shrink my tumor. Cancer did not spread either! Tumor marker continued to rise too. After 6 rounds of 5FU, my oncologist switched me to gemcitabine/abraxane. After several treatments, my CA19-9 has dropped significantly! I hope it means my tumor is shrinking! My very best to you!

My husband has been on gemabraxane for 2 and a half years. The first 25 months or so were with a trial drug, which didn’t pan out. He has continued with the gemabraxane since. Tumors shrunk by half during the first year and have remained stable. . No spread. 19-9 dropped to normal in the first year and has been fluctuating a tiny bit since June.

My husband had first treatment of gem/abrax today. Nice to be able to read of everyone else's experiences with it. Dan is 70. Had 12 treatments of folfironox, then about 6 of reduced maintenance sessions. CA19-9 numbers went up 4 or 5 times, so 3 more full treatments of folfironox. CT scan showed new growth in two lymph nodes at the back of the abdomen, though other spots in lungs, pancreas, bones showed no grown, so today changed to gem/abrax. Still too early to see how he will react to it. It really was nice though how it was a shorter day of infusions! We were used to 11 hour days (with the drive in/out) of blood draw, oncologist visit and infusions of hydrations and folfironox. Now a shortage of hydrations, so not offered and the gem/abrax were a lot quicker! Fingers crossed that it works and the side effects aren't terrible.

Hi Myacim… you mentioned “two rounds” of Gemcitabine /Abraxane. Were these individual treatments or a number of treatments per “round”?

God bless and the best for him❤️

This week was only 1 drug. He did much better this week! Still lack of appetite but was more active. He actually played a full round of golf yesterday. Tired him out but he had a great nights sleep! Staying positive 👍

How is he doing with the second treatment? Did you share with the chemo nurse the symptoms he experienced with the first round? We're they able to help?

Thankyou. The first dose has taken a huge toll on my husband. Not sure how he’s going to do with his next treatment on Monday. We may have to do the same. Stomach pain is his biggest issue

My dad began on the Folfurinox 5fu- chemo regimen. Then switched to the Gem/Abrax. We tried to do that treatment plan but after week two we had to switch to a one week on/one week off plan. It was too much for him to handle. The Gem/Abrax really took a toll on him but switching the treatment plan definitely gave him some time to recover.

It is so difficult. I found that protein shakes helped after chemo for my dad. He was reluctant to drink them but I just kept encouraging them. Take it easy - sending positivity.