1. < Prostate Cancer
Profile picture for xahnegrey40

Game changer for us high risk guys? Adding enzalutamide to ADT

Posted by xahnegrey40 @xahnegrey40, Oct 20 8:57am

https://www.sciencedaily.com/releases/2025/10/251019120507.htm

A groundbreaking clinical trial has revealed that adding enzalutamide to standard hormone therapy can cut the risk of death by more than 40% in men whose prostate cancer returns after surgery or radiation.

so this seems to be in use already..what are the side effects ?- they sound similar to all the other ADT stuff...unpleasant..

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

Profile picture for hbp
hbp | @hbp | Oct 20 10:20pm

Thank you North…that is a helpful explanation of the 4-5 year prognosis. That prognosis really upset me and caused my wife and I to put our affairs in order. We did not wish to be a burden on our kids. I’m now 78 and our business affairs are now in order but we have 2 large homes that are full of stuff and we have no plans to downsize. The kids will handle getting rid of stuff much like what my wife and I did when our parents passed.

REPLY
1 reply
Profile picture for northoftheborder
northoftheborder | @northoftheborder | Oct 21 5:08am
In reply to @hbp "Thank you North…that is a helpful explanation of the 4-5 year prognosis. That prognosis really upset..." + (show)
Profile picture for hbp @hbp

Thank you North…that is a helpful explanation of the 4-5 year prognosis. That prognosis really upset me and caused my wife and I to put our affairs in order. We did not wish to be a burden on our kids. I’m now 78 and our business affairs are now in order but we have 2 large homes that are full of stuff and we have no plans to downsize. The kids will handle getting rid of stuff much like what my wife and I did when our parents passed.

Jump to this post

@hbp Yes, the same thing happened to me. I remember lying alone, paralysed in a hospital bed at age 56, awake in the middle of the night trying to document everything for my family in a note on my phone. Dark times.

My younger daughter thought I wouldn't see her graduate (I did). I thought I might never walk again (I do) or go to the family cottage (I was there just over a week ago). I've been on a trip to Europe and crossed Canada by train. I'll meet my first grandchild in January, and now I've even lived to see the Blue Jays make the World Series again. (Hope that's not too controversial for the forum. 😉)

Don't give up, folks. Advanced prostate cancer is serious, and thousands do die from it every year, but our prospects are *far* better than they were just a few years ago. There's no guarantee we'll make it, but there's real hope now that didn't exist before.

REPLY
1 reply
Profile picture for johndavis60
johndavis60 | @johndavis60 | Oct 21 6:26am
In reply to @northoftheborder "@johndavis60 I think "4–5 years" (or 3–5) was the standard diagnosis for metastatic prostate cancer based..." + (show)
Profile picture for northoftheborder @northoftheborder

@johndavis60 I think "4–5 years" (or 3–5) was the standard diagnosis for metastatic prostate cancer based on the SEER database. They told me the same when I was diagnosed in 2021, though they soon backed off.

SEER is necessarily backwards facing, so it hasn't fully caught up with major recent advances in prostate cancer treatment, including new drugs like the -lutamides, and new treatment strategies like doublet/triplet therapy (or even just recognising oligometastatic as a separate category that can be treated with curative rather than just palliative intent).

So "4–5 years" is what @hbp and I might have expected a decade ago, not (necessarily) what we can expect in 2025.

Jump to this post

@northoftheborder
Thanks North!
I am also GL 9, CR + IDP.
Locally advanced. I’ve had surgery, I’m on ADT + Abi, and I’m doing radiation now. No one has ever given me a prognosis in years and I probably wouldn’t believe them anyway.

REPLY
Profile picture for xahnegrey40
xahnegrey40 | @xahnegrey40 | Oct 21 7:07am
In reply to @northoftheborder "@hbp Yes, the same thing happened to me. I remember lying alone, paralysed in a hospital..." + (show)
Profile picture for northoftheborder @northoftheborder

@hbp Yes, the same thing happened to me. I remember lying alone, paralysed in a hospital bed at age 56, awake in the middle of the night trying to document everything for my family in a note on my phone. Dark times.

My younger daughter thought I wouldn't see her graduate (I did). I thought I might never walk again (I do) or go to the family cottage (I was there just over a week ago). I've been on a trip to Europe and crossed Canada by train. I'll meet my first grandchild in January, and now I've even lived to see the Blue Jays make the World Series again. (Hope that's not too controversial for the forum. 😉)

Don't give up, folks. Advanced prostate cancer is serious, and thousands do die from it every year, but our prospects are *far* better than they were just a few years ago. There's no guarantee we'll make it, but there's real hope now that didn't exist before.

Jump to this post

@northoftheborder
thanks for that- I had some long nights this past summer-alone..I know what you are talking about...slowly things have gotten better and I have some hope...but a far cry from the mantra I heard for years: " dont worry about prostate cancer when you get older, they dont even have to treat it"

REPLY
View MoreView Less
Please sign in or register to post a reply.