Forteo and weight gain

Posted by me75 @me75, Dec 21, 2023

I’ve been on Forteo since my surgery 14 weeks ago and I have put on 20 pounds and I feel so uncomfortable and depressed . Is there anything else that would be as good to take with out the weight gain? Waiting desperately for help 🥲🙁

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@paulinea

I have been told that there are no indications for weight gain with teriparitide use? I have researched this before starting.
Would welcome feedback

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You can find associated information by looking at the effects of hyperparathyroidism on weight gain. Teriparatide's mechanism of action raises the serum levels of parathyroid hormone. High levels of parathyroid claim calcium from our bones, and kidneys and increases absorption from the intestine. but transciently unlike hyperparathyroidism. The loss of calcium in the bone engenders the processes that build bone.
But the increase in serum calcium draws calcium into fat cells. The extra calcium in fat cells prevents them from apoptosis--natural cell death.
In general postmenopausally women collect the most fat cells at the waist hips and thighs and this is where the calcium-happy fat cells become longer lived with both Tymlos and Forteo use.
If a clincal trial questions survey doesn't ask about weight gain, a participant is unlikely to enter information about weight gain. If a prescribed patient mentions weight gain it remains unreported. Instead patients are encouraged to pay closer attention what we eat and how much exercise we are getting. Whether a societal effect or biological, it is easy to get women to blame themselves.
It is recognized that hyperparathyroid patients are commonly more burdened with fat than their cohorts.
Some Forteo patients don't gain girth with the medication, likely because of their calcium status during the four hours of high parathyroid effect with the medication and perhaps a lower base level of normal fat tissue.
With the number of women experiencing the gain, I've not heard of even one of their physicians supporting the claim.
I've been on Forteo for 21 months and have not experienced extra fat. My calcium intake may be lower than optimal for bone growth.

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Very helpful thank you. I was diagnosed with hyperparathyroid disease and as a result had a benign tumor removed from parathoid gland in my neck. I believe i no longer have the disease as all levels returned to normsl and no further issues. Is that correct? I see comments about the disease, isint the tumor the cause?

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Yes, your post is accurate. The tumor caused hyperparathroidism removing it effected a cure.
Forteo is a parathyroid hormone analog. Injecting it raises the level of parathyroid hormone in your blood for about four hours after injecting. During that four hours the parathyroid hormone increases calcium in your serum. That calcium can leave the serum and enter your fat cells giving those cells long life.
The mechanism is easier to search under hyperparathyroidism, studies haven't been done with the osteoporosis medications.

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I completed 24 months of Forteo 5 years ago and did gain belly fat. I think the nausea and fatigue contributed to that, as well as some cravings for sweets without the energy to work it off. The bone density gain was actually well worth that for me, as bone fractures would have continued without that medication. I am now on generic brand of Forteo and one month in, no weight gain as I am more aware and eating only farm fresh, no processed foods and doing my best to eliminate sugar. Daily walking is part of my pain management, so I hope to keep that up as well. I just look at belly fat now, as sign the medication is doing it's job and I will stay more on top of it this time, or accept it and work it off later.

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