Finished with Pluvicto?

Wow, that's a pretty remarkable effect. Congratulations! And you're right, Pluvicto isn't for all. But it's great to see it working for some.

Did you go straight to Pluvicto for the recurrence or was anything else discussed? (Selfish question. Currently on Taxotere but if something else is needed, Pluvicto isn't in my toolbox)

Howdy and thanks...yes...Fortunate?...lucky?...blessed?...either way, I'll take it.
And there are no selfish questions...we're all in the same boat...
All kidding aside, since the PSMA-PET from last November indicated activity in both bone AND soft tissue, I was a candidate for Pluvicto. Locally they only administer Xofigo (more for bone metastases only), so I had to travel for the Pluvicto. Nothing other than that was discussed...'turns out that was the correct therapeutic for me...(lucky!!).
Nowadays I've read that Pluvicto can be used ahead of Chemo...but it seems too late for the both of us to know that...Taxotere was also very effective for me with very few side effects other than hair loss, but most of it grew back.
Blessings in your path!

For your prostate lesion, have they considered focal cryosurgery?

Is the only metastasis to bone?

Howdy,
I've not seen the detailed scan results. It was a hot spot, but not necessarily a lesion, so I can't say empirically......there is a saying: "Not all that glows is a lesion..." ...food for thought...

Blessings

I'm currently stage 4 with a Gleason score of 9. I opted for radiation and ABT instead of surgery and my PC went into remission for 5 years. It came out of remission last August and spread to my lungs (very unusual) and I had lung surgery where they did a lung resection. I then went on Abiraterone, Lupron and Predisone, which has so far kept the remaining lung nodules in check. I'm told the PC in the lung will eventually become resistant to the drugs I'm on. My oncologist said I'm very likely eligible for Pluvicto, so I'll probably be faced with the choice of chemo or Pluvicto.

My question to deccakid is this: since you've had both chemo and Pluvicto, which one was the most taxing treatment?

@tom99
Howdy,
A good question, since both can have debilitating side effects...
I've been extremely fortunate, as i've posted, with very few nasty side effects in all my treatments...Chemo really didn't bother me that much...sure, I lost my hair but that grows back. The Pluvicto is a different beast. I do not want to dissuade you, because the results are FAR more important than the relatively short term effects, but I found Pluvicto simply wiped me out. Napping/sleeping much of the day sometimes in addition to the nightly sleep...and the dry mouth/throat bothered me more than most because I'm a singer...
I'm also fortunate that I am semi-retired and live by myself, so no one to affect with the residual radiation. I was able to do important duties, I never lost my appetite nor had a change in weight (with either, actually)...
However, it was extremely effective for me...as I said that's what truly matters...I'm a walking encyclopedia about Prostate cancer with regard to metastases to lymph, bone and soft tissue (Prostate) but know nothing about metastasis to the lungs...That's above my pay grade...LOL...
I can only advise you to ask a LOT of questions, do a LOT of research (and take everything with a grain of salt)...Pray and laugh...Yes, LAUGH!!...Laughter IS a medicine!
Best regards and blessings to you on your path!!

Great information! There is very little information about lung metastases, compared to bone an lymph metastasis, and nothing on lung metastases used with Pluvicto, so your feedback on Pluvicto helps a lot.

I've only been able to find a couple of people with lung metastasis after searching both here and at prostatecancer.net, so if anyone with lung metastasis AND has had Pluvicto, I'd love to here from you.

@tom99
Because I like research and, strangely, find cancer intriguing (I just wish it wasn't in me!!) I googled a couple things re: metastases to the lungs:
"How Pluvicto Works on Lung Metastases
• Targeted Delivery: Pluvicto uses a PSMA-targeting ligand that binds to protein receptors on prostate cancer cells—including those in the soft tissue and lungs—and delivers short-range beta-radiation (about 2 millimeters) directly to destroy the DNA of the cancer cells while sparing surrounding healthy tissue.
• Visceral vs. Bone/Nodal Disease: Clinical data and specialist guidance from centers like The University of Kansas Cancer Center note that PSMA-positive cells in visceral organs like the lungs can be reached and treated by Pluvicto.
• Patient Selection: Eligibility for lung or other soft-tissue metastases depends strictly on whether the lesions are PSMA-positive on a specialized PSMA-PET/CT scan. If the lung metastases show strong PSMA expression, Pluvicto can be part of the treatment plan".

There is more out there but you have to dig deep...and, again, often times read between the lines and take all with that grain of salt...
Blessings

These are essentially the things I found in my research, which reinforces the idea that there isn't a lot out there on actual cases of patients with lung metastasis that had Pluvicto, and their results.

The lack of info on lung metastasis is pretty frustrating and I'm still hoping someone here has direct experience with this.

Thank you for your thoughtful response - it's obvious you put some work into it and I really appreciate it.

Here's hoping for best with your treatment.