Fatigue while on Abiraterone + Prednisone + Lupron Depot

Make sure you taper off the prednisone over a couple of months. You will have fatigue like you’ve never experienced before if you drop it too quickly.

More prednisone does make a major difference in fatigue for many people, Some doctors start off with 10 mg as the recommended daily dose others five mg. Many people have a fatigue problem with 5 mg.

At age 66, I began the same regimen as your husband. I just finished my two-year stint in October. I was very active prior to treatment and was able to remain active for a little over a year. Then the cumulative effects of the treatment hit me, and I was tired all the time, and took many naps and didn’t have the energy to exercise. I was on a 5 mg dose of prednisone, but I didn’t want to up it, because my osteopenia had already become osteoporosis (I was given Reclast to deal with that). My ADT ended this past October, and over time I’ve felt better and better. I’ve become active again and almost feel my old self. I hope this information helps and gives you and your husband something to look forward to.

Thank you so much for sharing with me. I hope we have the same results as you have had. I’m so glad to hear that you are feeling much better. Best wishes to you go forward and thank you again!

I've been taking abaraterone and prednisone daily for 1.5 years also. I have the very same symptoms. My oncologist has told me this is typical. I also experience terrible episodes of hot flashes. They usually last only a few hours at a time, but they leave me drained of any energy.

I left out the horrible hot flashes - my hubby suffers from them as well. Our doctor told us the same. Im just wondering what happens when we stop all of this. We have 6 months to go.

Thank you or commenting - it is nice to know that there is someone who is exactly where we are!

I had the same hot flashes issue you had.

As a hot flash was hitting I would feel a lot of fatigue. After a year, my oncologist prescribed a depo-provera shot every three months and it really stopped those hot flashes on Lupron. There are other hormones that can do this, speak to your doctor.
When I went on abiraterone The hot flashes came back, but not quite as bad.

Solutions
I know one person that says eating tofu every day really controlled his hot flashes, another person in this forum said the same thing. Can’t hurt to try it. Black Cohash is also said to help. Acupuncture works for some people.

I have an embrlabs.com wave product (wave 2). I’ve used it for Over three years now. It’s like a refrigerator that looks like a watch and sits on the inside of your wrist. You could set up one of the buttons for their night mode . Hit the button twice and It Produces cold waves at measured times during the night and prevents hot flashes and night sweats. They used to bug me, before I got this device . When you start to feel a hot flash coming on, you hit another one of the buttons twice and it sends cold chills through your arms and it reduces the intensity, shortens the life and can stop the hot flashes if hit quickly enough. If you get the device, I can give you instructions on how to configure it the best way for hot flashes.
https://embrlabs.com/