Experience with Triplet therapy followed by IMRT and SBRT

Posted by bka2 @bkandrew, Jul 15, 2025

Hello and thank you for reading this. I’m 62, G9 with 3 bone metastases and a couple involved small pelvic lymph nodes (de novo oligometastatic prostate cancer). Currently, I’m on dual hormone therapy and will begin docetaxel in mid August (6 cycles, one every three weeks). The plan after chemo, assuming all goes well, is to have radiation to my prostate and to the spots where mets were. I will remain on hormone therapy for a year after I complete radiation. I know I need to hit this as hard as I can from the start but it seems like such a large undertaking and I don’t know what to expect along the way. Not sure how I will feel during chemo and radiation.

I was hoping to hear from some of you, who have been through the same treatment, what your experience was or currently is, how you handled it, and how you’re doing post treatment.

Thank you in advance for sharing your experiences. I really appreciate your support.

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

We got by with one pair. We kept them ‘assembled’ in our freezer and fill a small cooler with bags of ice, load the frozen mittens/socks, top it off with more bags of ice, and take the cooler. We put the mittens/socks on 15 min before the start of the docetaxel which comes first and left them in til about 15 after the Carboplatin, a total of 1:45-2hrs. Some say it’s only the docetaxel that can impact neuropathy, but we just kept them on. If the items don’t stay cold, we have the ice… but haven’t had to go that route. If you can afford a 2nd pair , that would be awesome if you can keep them cold. Good luck and from what I hear of neuropathy from chemo, it’s work the effort.

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Profile picture for wooldridgec @wooldridgec

Yes. I had SBRT radiation to the bone mets to my spin and ribs before starting ADT, but while on Casodex for 30 days. The cancer manifested itself through intense pain in my back. That is why the doctors immediately started me on SRBT radiation. The radiation treatment for the first 5 cycles to the spin were easy. After 5 it got very difficult. I felt burned from the inside out and I struggled to eat and to keep weight on. The doctors forgot to radiate my ribs. So, after completing 10 cycles to my spin they immediately called me back to radiation the ribs for 5 additional cycles. I lost 35lbs. After the treatments were over, I would say 3-4 weeks later my appetite started returning and I was much better. But then I immediately started chemo. I was told by my doctors that starting chemo in the first 3 months of treatment was vital for overall treatment. My wife did some research before I started radiation and found Studies suggest that blueberry extract may enhance the effectiveness of radiation therapy in treating certain cancers like prostate cancer. I do not regret getting radiation - but it was probably the most difficult treatment in my journey. Others that get radiation to the prostate bed do not have the same experience. It is much easier. I have a friend who just finished radiation of his prostate and prostate bed and he says it was easy. I think when you have radiation to the spin and ribs it is going to the organs and stomach which cause more challenges. So, in fact I have had quadruple therapy - radiation, ADT, ARSI (i.e., Nubeqa), and 10 cycles of Chemotherapy. Oh, I also get a shot of Xgeva every 6 weeks for my bones. July 27 is my birthday and the day I was diagnosed. I just want to get past it as I do not celebrate that day anymore. Again, treatment is between you and your doctor. Everyone's cancer is different. That is what scares me. It is unpredictable. Do not listen or accept anything on the internet. Many men with stage 4 prostate cancer live past the cancer and die of something else. Overall survival depends on several factors, how effective your treatment is, your age, and your overall health. My first doctor told me I could live, 5, 10, even 15 years with this disease. Another said he had people living with this disease 15, 20, and 25 years long but the average was about 6 to 7 years. Those stats were before triplet therapy and Nubega (i.e., Darolutamide). Right now the doctors do not know hw long men who have successfully completed triplet therapy will live. Because we are all still alive.

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@wooldridgec
Thank you for posting this.

Hubby is doing triplet therapy now for stage 4 G8.
First round of six chemo done.
His also manifested in extreme back pain. Relugolux helped tremendously within a couple of weeks. Darolutemide and docetaxel added.

We have an appt to talk to the radiologist right before round 2 of chemo. Not sure what to expect.

His GP delivered the diagnosis in a way that made us think there was really no hope. After appointments with the oncologist and other specialists, we now know while there isn’t a ‘cure’, there’s hope.

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