Exercise as a Prostate Cancer treatment

Exactly what both of my doctors (medical and radiation oncologist) told me this week actually more effective then diet both said that moderate exercise can stop or slowdown progression but don’t neglect a healthy diet
Zzotte

@kujhawk1978

I only hit the gym three days a week and definitely not as much work as you do, but I also run a mile twice a day.

And then there’s running which doesn’t seem to be all that prostate cancer preventative, but read these article articles which talk about how it stops prostate cancer from growing. Not sure whether you’ve seen these articles..

Running and prostate cancer
https://pmc.ncbi.nlm.nih.gov/articles/PMC12535562/
https://bioengineer.org/exercise-conditioned-serum-inhibits-prostate-cancer-growth/

hello All:
I just watched a video from 9 mos. ago with Dr. Robert Newton that was different from the conference, with a question and answer by a host. See

I heard/read recently that one of the factors influencing PC survival is loss of muscle mass. I started training at the local Y 2X weekly using the six exercises mentioned during Dr. Newton’s PCRI session.

@jime51

One other thing to consider

Running and prostate cancer
https://pmc.ncbi.nlm.nih.gov/articles/PMC12535562/
https://bioengineer.org/exercise-conditioned-serum-inhibits-prostate-cancer-growth/

@jeffmarc I've had three knee replacements and a hip replacement. My orthopedist says I can walk but not to run or jump. I think I"m paying for jogging on pavement for too many years while overweight. Good memories, though!

Actually, this is a good subject.
I've been losing weight below the waist (as evidenced by never-ending new holes in my belts/pants falling down problem) but still hold weight above the waist (as evidenced by my 9-month-pregnant belly).

I thought maybe it's because my appetite has drastically reduced (another mystery) but then I thought maybe it's because I haven't been doing my 10 000 steps per day that I used to.
Maybe it's just muscle loss. With 2 ops in 9 months, I haven't exactly been mobile over the last 18 months.
Guess I should start walking again & build up strength. I'm so used to hobbling around the house like a cancer patient.

Hello:
I am a firm believer in exercise for cancer, and go to the gym 3-4 days a week and feel great. I can absolutely say that it made the 6 months on Lupron a walk in the park. However, other than Dr. Rob Nuton's belief, does any body else here have any quantifable evidence that shows that exercise actually works, such as a drop in PSA, or lengthing of doubling time, etc.
Thanks

@denany
I implemented a modified cardiovascular exercise routine based on the results of the ERASE randomized clinic trial performed in 2021:(https://jamanetwork.com/journals/jamaoncology/fullarticle/2783273)

ERASE conclusion: "The ERASE trial demonstrated that HIIT increased cardiorespiratory fitness levels and decreased PSA levels, PSA velocity, and prostate cancer cell growth in men with localized prostate cancer who were under active surveillance."

I was diagnosed with low volume 3+4 and Decipher of 0.22 in October 2023. I increased my running routine to three 5K's per week and added HIIT, at that time.

My most recent PSA level is 25% below my prebiopsy level and a follow-up mpMRI indicated that two of the three original PIRADS lesions were not visible and the largest had shrunk and its T2 & DWI/ADC signals reduced from “moderate” to “mild”.

So, yes, there is quantifiable evidence, based on a randomized clinic trial (the "gold standard" of medical research) that cardiovascular exercise does slow prostate cancer progression. I have experienced these same results 29 months after diagnosis and implementation of my cardiovascular exercise protocol.

I posted a lot more detail about my experience earlier in this thread.

@handera
Thought I'd post my latest cardiovascular exercise protocol and their results.

To provide context, 3 1/2 years ago (at 66 y/o) when I started, I could only slow jog 0.25 mile and had to stop due to exhaustion...

Yesterday, at 69 1/2 y/o, I ran my fastest 5K yet (8:09 min/mile).

I had not attempted a "fast" 5K for over a year, yet my endurance training allowed me to set a personal record.

My normal protocol is to run three 5K runs per week at a sustainable Zone 2 pace of ~10:00min/mile (70% - 75% of my max heart rate)...a very sustainable pace. I have maintained this kind of Zone 2 pace for as long as 15K.

After my typical Zone 2 5K run, I do two 0.25 mile runs at a 6:00-6:30 min/mile pace (my HIIT training)....no where near a classic Norwegian 4+4 HIIT trial...but IMHO that type of HIIT is not necessary to obtain ERASE RCT observed results.

I also do 3 sets of 10 push-ups prior to every 5K run (my "strength" exercise)...that's it!

I'm not a physician (a retired chemical engineer) and this is not medical advice. Consult with your doctor if you are not currently running or cycling before attempting anything like this.

I'm posting simply to encourage those who may be where I was in July 2022...unable to slow jog more than a quarter mile....and to show the possibilities of slow & steady endurance building cardiovascular exercise.

All the Best!