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Evenity New
I used the heading Evenity new because I’m not sure
where this discussion fits in.
Clinical Studies on osteoporosis drugs:
Evenity was approved in the U.S. and Canada around 2019.
CHMP in the U.K. would not approve of Evenity in April 2019
because of negative cardio events.
Amgen stated then it would apply for re-appraisal.
Amgen was under pressure at that time because another
of their meds was getting off patent.
And Amgen was worried that another osteoporosis med
was going on market and take market share away from them.
I think it was a PTH med.
In Oct of 2019, CHMP made a quick U turn and approved
the drug Evenity.
Clinical Trials on Evenity: several co-authors of study on Evenity
are mentioned: one or more in particular are
in private practice. Is this a conflict that should concern
us as we read the results. *look at bottom of study to see
participants.
I could link to studies: however I have so many publication/articles/etc
it would take me some time. Suggest if you are interested
to pursue any subject, do some browsing on web, lots there to find
from credible sources.
I now am doing some research on more info on the PTH meds.
I want to clarify:
I am NOT advocating or trying to influence any decision,
that anyone has on what to take or not take.
What is good for you is good for you. You have made the
best decisions for yourself under stressful conditions.
I am very motivated to get the best research, the most
up-to-date information on anything I put into my body.
I have severe osteoporosis and still have not come to a
decision on what med to take, or not take.
Drs. anyone I’ve seen, have said they have hardly ever
seen my numbers.
This is one year since my diagnosis.
The first several months since diagnosis
were confusion and fear. I am trying not to make a decision
based on fear.
I have read, and continue to share in the good news of
people in this Support Group. I say Hurray for good news
and improvement. You are pioneers in a very uncharted
journey.
Next: I know you are all aware of how balance is important.
Don’t fall. Do we have a separate discussion group for
best exercizes to prevent Falls, to strengthen spine muscles,
compound exercizes, farmer walk, bird dog, etc for osteoporosis.
regarding nutritional benefits for osteoporosis:
Is there a separate support group for Nutrients:
Has anyone taken, or is taking, these additional vitamins/minerals:
omega 3
magnesium
broccoli sprouts - Sulforabane
Dr Patrick has interesting views: take a look
Vitamin/minerals made by Metagenic, Thorn,
Has anyone bought from these supplier: There is also
Consumer Lab for helpful info. I have not checked
with them lately.
In addition to Vit D and Calcium..what are your views:
strontium citrate: to add to your diet - is it controversial?
Melatonin – some clinical studies ..take a look
very promising for bone health. Do you take any.
Am still trying to find right dietitian, have not so far.
Finally: the Marydone vibration, which got praises from
Dr Janet Rubin with Margaret Martin interview,
(btw Dr Janet Rubin is related to Dr Clinton Rubin)
Sara Meeks also endorsed it on a Bob and Brad interview.
It is so expensive. Has anybody
found a similar machine, same configurations, at lower cost.
I am happy to read, and share with others about meds
and beyond with nutrients and.. anything else
can be beneficial. thank-you
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"He has not followed up with any other treatment."
Women lose estrogen suddenly at menopause. Men only lose testosterone comparatively with specific treatment for cancer.
Women's vulnerability is why it is so typically a woman's disease.
I only know of Dr. McCormick through posters on this site. No one ever says anything negative about him. Without reference to him, you might cautiously remember that osteoporosis is a different disease for women.
@gently
I am a bit perplexed by your comments.
Your comment
that osteoporosis is mainly a women's disease.
It seems there is a higher prevalence for women to have it.
Some of the possible reasons are:
Women live longer.
Women sometimes are more pro-active in their health.
It might take an event, like fractures from a fall,
either a woman or man
to realize they have osteoporosis.
There might be people of both sex
with osteoporosis that
don't have debilitating symptoms or fractures.
They may have minimal discomfort, and decide
not go to doctors.
Both women and men get osteoporosis.
Women get osteoporosis in a different timeline than men.
A woman's menopause has a large role
in her getting menopause.
The protective estrogenic decline happens sharply
around the time of, during and after menopause.
Apparently genetics and nutrition also has a role in
osteoporosis.
That's what the current thinking is, until it's reversed
or modified. Information does change: meat is bad for you,
meat is good for you: eggs are bad for you, eggs are good
for you. Medicine is constantly evolving. Think of Covid.
Think of scurvy and rickets. These are bone conditions caused
by nutritional deficiencies.
your comment about Dr McCormick
I wasn't aware that I was, nor was it my intention in any way
to say anything negative about Dr. McCormick.
I asked a question. About his dexa score of -3.3 after his
treatment with meds.
A dexa score of -3.3 is concerning to doctors and
if a patient shows up with these numbers
their advice is to address it before it gets worse.
This medical advice is whether it is a woman or man.
And I was curious: was Dr McCormick taking further
osteoporosis meds to improve his dexa score.
And if he was not
taking meds, what else he was doing to be able to
train, or compete in IronMan - which is quite energetic.
Finally, I don't think osteoporosis is a different disease
for women than men.
The condition is similar for women and men
and so are the remedies, drugs or not.
It is simply that: I was curious and asked
questions.
Asking questions, I think, is the way to help us
be better informed and make better decisions.
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2 ReactionsI know someone on this thread gave a good lesson
on how to find
a member's previous posts.
I tried it and failed.
I need another lesson 🙂
In response to my comments-
I am seeking new input from Cleveland clinic and one other in addition to researching more intensively. I expected an improvement after my 3rd year dexa scan in 3 years on alendronate, but nothing This is not a specialty dr and there aren’t many specialists in the area. Saw an endricronologist still in Physical therapy No breaks or fractures yet. Healthy overall
Also dexa was 3.7. 2022
-3.5. 2023
-3.7. 2024
Requested a dexa at 62 years. Was put on alendronate via primary care Dr seeing the -3.7 in 2022,
Sorry,
I found it clear that you were interested in consulting with McCormick. He has been helpful to every poster that I've read. Any implication that you were negative about the dr is not in my post.
I haven't commented on his medical situation or on how he advises patients.
I suggest for consideration that the difference between sudden estrogen loss for women and gradual testosterone loss for men makes it safter for men to eschew pharmaceuticals than it is for women. I think that is the only part of my post that you disagree with.
You agree that more women than men experience osteoporosis. You agree that estrogen is a factor. And perhaps disagree that mens ability to maintain testosterone doesn't change their experience of the disease or its treatment.
I respect and value your questions and your disagreement.
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