End of treatment (I hope)

Posted by garylr @garylr, Mar 19 8:21am

First diagnosed in April 2023 at age 66, after blood work for a routine physical came back with a PSA of 8.2. Urologist re-ran the blood test, and it returned a PSA of 6.5. MRI indicated a couple of PI-RADS 4 lesions, confined to the prostate. TRUS biopsy came back positive for the areas the MRI had highlighted - Gleason 6. Started active surveillance. Next PSA, October 2023 was down to 5.7.

Then blood work last April came in with a PSA of 9.1. Re-test by the urologist came back at 10.9. Second MRI report said nothing had changed. Second biopsy (a "saturation" biopsy, with 28 cores) came back with a mix of Gleason 6 and Gleason 3+4 results. Genomic test score put me at a little above average risk for adverse results. So we decided to treat it. I was leaning toward radiation therapy and Urologist and Radiation Oncologist both said I was a good candidate, so we went that route, along with six months of ADT.

3-1/2 weeks into ADT (and about a month before the start of radiation treatments), blood work had my PSA down to 3.4 and T down to 7 (from 485 in April). So the Orgovyx was doing its job.

Wrapped up 28 sessions of EBRT on 12/31/24. Side effects from that have pretty much disappeared. Took the last of 180 doses of Orgovyx this morning. Looking forward to a slow climb back to something resembling "normal" starting tomorrow.

Have a blood draw scheduled for 4/14/25 - the first since the end of radiation. I have my fingers crossed!

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

Robert.
Have had identical experience. Doing blood draws mid-late April 🤞🏻

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@rparsons

Gary, I too will have my blood drawn next month around the same time as yours. First one since I ended hormone therapy.
I also did 28 rounds of radiation & 18 month of adt. I have to admit I am a little nervous. Are you experiencing any anxiety, or are you calm as a cucumber ? 🥒

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@rparsons - No anxiety, really. I tend to be an optimist, so I'm expecting good news. A little impatient, I guess.

Hope your numbers come out good!

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An update:

Blood work ~3-1/2 months post-radiation therapy and ~4 weeks after finishing up 6 months on Orgovyx came back with a PSA of 0.08 (RO doc says she's pleased with that) and testosterone at 35 (was at 7 in October). My PCP looked at a bunch of other stuff as part of my annual physical - kidneys, lungs, blood sugar are all good. EKG was good. Liver enzymes were a little high, but he didn't seem alarmed - check again in six months. Only other issue is that a "body composition analysis" says I've added about 20 pounds of fat to my body in the past year. Good news is I only lost a pound or two of muscle mass. Diet time!!

Hoping that the T continues to rebound. Still not much interest in sex, but there have been some morning erections lately - so, maybe making some progress.

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@garylr

An update:

Blood work ~3-1/2 months post-radiation therapy and ~4 weeks after finishing up 6 months on Orgovyx came back with a PSA of 0.08 (RO doc says she's pleased with that) and testosterone at 35 (was at 7 in October). My PCP looked at a bunch of other stuff as part of my annual physical - kidneys, lungs, blood sugar are all good. EKG was good. Liver enzymes were a little high, but he didn't seem alarmed - check again in six months. Only other issue is that a "body composition analysis" says I've added about 20 pounds of fat to my body in the past year. Good news is I only lost a pound or two of muscle mass. Diet time!!

Hoping that the T continues to rebound. Still not much interest in sex, but there have been some morning erections lately - so, maybe making some progress.

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Sounds like you are on a good path, Gary. That lower belly fat can be quite persistent. I did not gain more than 5 pounds but it’s all right there.
Hope that the increased T and the somewhat less than voracious appetite will help in that respect!
Phil

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