Effect of surgery wait times on post op pathology.

The majority of prostate cancer is slow-developing, so a few months shouldn't usually matter: as someone else mentioned, if you see a different Gleason score post-op, it's typically because the biopsy needle missed something in the haystack of your prostate.

But there are exceptions. A minority of us have very fast-moving cancer that can escape the prostate rapidly. My metastasised tumour grew so fast that it compressed my spine within a month and left me paraplegic for over a yeae. Typically, you'd be seeing Gleason 8 or 9 with a cancer like that (and even most of them don't spread that quickly).

So most likely, the delay wouldn't matter (especially if the Gleason score in the biopsy was low), but there's always a tiny risk.

@shalom7777777
This does sound like a pretty safe solution. While you do have active prostate cancer, it is not real aggressive from the looks of your biopsy.

Waiting a few months is not gonna make a difference. If they find a higher Gleason score after the surgery It probably won’t be much more aggressive,.

The odds are in your favor.

@kenhorse
Thanks for sharing Ken! you lucky guy! Your decipher score is low I guess.

This study from 2020 reported in JAMA indicated that even with localized, high-risk prostate cancer, a delay of up to 6 months has no statistically significant chance of worse outcome. —> https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2773817

This 2019 paper out of the UK indicated that initial biopsy and pathological grade matched 59% of the time, while upgrades occurred 25% of the time and downgrades occurred 16% of the time: https://bmcurol.biomedcentral.com/articles/10.1186/s12894-019-0526-9