Edema and Lyrica

Posted by danye1 @danye1, Dec 4, 2022

Has anyone definitely associated ankle and/or leg edema with taking Lyrica? I have noticed bilateral, mild swelling at the ankle since starting Lyrica to address SFN pain. The swelling clears up by morning.

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Hi @danye1, I've have neuropathy with no pain so have never needed to take Lyrica (Pregabalin). I do have mild swelling in my legs (lymphedema) for which I wear compression socks daily. Edema and swelling is listed as one of the side effects of the drug.

— Peripheral edema with pregabalin:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708031/
— Peripheral edema associated with low dose of pregabalin in an older person:
https://www.jgmh.org/text.asp?2020/7/2/105/307589

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