Duodenal Mucosal Resurfacing (DMR)

Posted by ltssjs @ltssjs, Sep 1 1:24pm

Is this procedure now available for Type 2 Diabetics? If so, where and if not, when is it expected to be available? It sounds very interesting and promising to patients but obviously not to Big Pharma!

Hello @ltssjs,

I appreciate this interesting question. I had not heard of Duodenal Mucosal Resurfacing prior to your post. Are you interested in this topic for yourself as a Type II Diabetic?

I did google the term and came up with information from the NIH website. Here is the link to that information about clinical trials for this procedure, https://pubmed.ncbi.nlm.nih.gov/31331994/. Perhaps some other members of the Diabetes discussion group will have more information.

In looking at Mayo Clinic's website I did not find any information on this, only on the topic of Endoscopic mucosal resection. I think this is done for different reasons. Here is the link to that article from Mayo https://www.mayoclinic.org/tests-procedures/endoscopic-mucosal-resection/doctors-departments/pdc-20385214.

Has this procedure been suggested to you by your doctor? What results would you hope to achieve by this?

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@hopeful33250

Hello @ltssjs,

I appreciate this interesting question. I had not heard of Duodenal Mucosal Resurfacing prior to your post. Are you interested in this topic for yourself as a Type II Diabetic?

I did google the term and came up with information from the NIH website. Here is the link to that information about clinical trials for this procedure, https://pubmed.ncbi.nlm.nih.gov/31331994/. Perhaps some other members of the Diabetes discussion group will have more information.

In looking at Mayo Clinic's website I did not find any information on this, only on the topic of Endoscopic mucosal resection. I think this is done for different reasons. Here is the link to that article from Mayo https://www.mayoclinic.org/tests-procedures/endoscopic-mucosal-resection/doctors-departments/pdc-20385214.

Has this procedure been suggested to you by your doctor? What results would you hope to achieve by this?

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Yes, I am interested for myself and all Type II diabetics. I first became aware of DMR in a very short article in an AARP publication regarding a Netherlands study. I then read an article on a US study being done at the Univ of Penn. It sounded very promising and the procedure is not complicated. As my cardiologist said to me, "We have got the plumbing down pretty well and in the next 15 years their will be great strides in the electrical". He was referring to Ablation procedures which are utilized in heart procedures. In my mind DMR is an ablation procedure to be used in a diabetic procedure. It has always concerned me that we have never heard of studies being undertaken regarding the treatment of Type II diabetes which is so prevalent in our today's society. WHY IS THAT! I asked my Endo that question when I was discussing DMR with him. He was aware of the DMR study being conducted at Penn but in answering my question he candidly stated big pharma would never fund any such studies. Well, with the # of Type II diabetics out there we should be able to have the government fund such studies. Furthermore, it is mind boggling to me that DMR doesn't show up on the Mayo Clinic website. That is really disturbing. Any potential treatment of Type II diabetes SHOULD NOT BE IGNORED nor hidden. As you can tell this has me a bit riled up. A very basic and simple understanding of the DMR procedure is that it removes the cells that are interfering with effectiveness of insulin. That is a considerable achievement for a Type II diabetic!

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@ltssjs

Yes, I am interested for myself and all Type II diabetics. I first became aware of DMR in a very short article in an AARP publication regarding a Netherlands study. I then read an article on a US study being done at the Univ of Penn. It sounded very promising and the procedure is not complicated. As my cardiologist said to me, "We have got the plumbing down pretty well and in the next 15 years their will be great strides in the electrical". He was referring to Ablation procedures which are utilized in heart procedures. In my mind DMR is an ablation procedure to be used in a diabetic procedure. It has always concerned me that we have never heard of studies being undertaken regarding the treatment of Type II diabetes which is so prevalent in our today's society. WHY IS THAT! I asked my Endo that question when I was discussing DMR with him. He was aware of the DMR study being conducted at Penn but in answering my question he candidly stated big pharma would never fund any such studies. Well, with the # of Type II diabetics out there we should be able to have the government fund such studies. Furthermore, it is mind boggling to me that DMR doesn't show up on the Mayo Clinic website. That is really disturbing. Any potential treatment of Type II diabetes SHOULD NOT BE IGNORED nor hidden. As you can tell this has me a bit riled up. A very basic and simple understanding of the DMR procedure is that it removes the cells that are interfering with effectiveness of insulin. That is a considerable achievement for a Type II diabetic!

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@ltssjs, Duodenal Mucosal Resurfacing (DMR) research in people with type 2 diabetes is still in the early stages. Phase 1 research studies efficacy and safety in small numbers of people. Once (and if) efficacy and safety can be proven, the research will move to larger numbers of people for phases 2 and 3.

DMR is not being ignored. It is being studied. And research takes a long time, which is important to be sure it works, but unfortunate for people who are looking for answers now. This phase 1 trial will have results in Feb 2021
– Safety & Effectiveness of Duodenal Mucosal Resurfacing (DMR) Using the Revita™ System in Treatment of Type 2 Diabetes https://clinicaltrials.gov/ct2/show/NCT03653091

This blogger does a good job in breaking down the information from the study:
– Diabetes BS or Legit: Does Duodenal Mucosal Resurfacing for Better Blood Sugars in Type 2 Diabetes REALLY WORK? https://type2andyou.org/2020/06/30/diabetes-bs-or-legit-does-duodenal-mucosal-resurfacing-for-better-blood-sugars-in-type-2-diabetes-really-work/?v=868f8823ca02

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Colleen : Thank you for your reply but I don't believe your reference incorporates or reflects the DMR studies done in the Netherlands(&possibly other European studies) and the Univ of Penn study which is at least one such study taking place in the US. I believe the BS reference is just another callous disregard to further big pharma's interests by your blogger. So far these studies have shown they are legit and show achievement. The efficacy, most likely financial, seems to be the only unknown. The fact that this revelation came about thru unrelated surgery and is seemingly being challenged because of that is so bogus that it undermines the credibility of the challenging source. ANYBODY, AND I MEAN ANYBODY, concerned as to or about Type II diabetes should have DMR on their radar screen and authoritative sources should not be ingenuious or resort thereto.

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@ltssjs

Colleen : Thank you for your reply but I don't believe your reference incorporates or reflects the DMR studies done in the Netherlands(&possibly other European studies) and the Univ of Penn study which is at least one such study taking place in the US. I believe the BS reference is just another callous disregard to further big pharma's interests by your blogger. So far these studies have shown they are legit and show achievement. The efficacy, most likely financial, seems to be the only unknown. The fact that this revelation came about thru unrelated surgery and is seemingly being challenged because of that is so bogus that it undermines the credibility of the challenging source. ANYBODY, AND I MEAN ANYBODY, concerned as to or about Type II diabetes should have DMR on their radar screen and authoritative sources should not be ingenuious or resort thereto.

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@ltssjs, I'd appreciate learning more. Can you post links to the studies that you mentioned?

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The Netherlands study info was from an AARP publication and the Univ Of Penn study info was from a daily newspaper. But as I said even my Endo knew of these studies. An internet search most likely would be beneficial. What really caught my attention was the ablation/cell approach that has been so effective in cardiology. I believe medical procedures will be greatly expanded upon and knowledge will be gained from one discipline/approach/arena that will be applicable to another. As is the case with DMR. However, understand my understanding of DMR is that it pertains to the effectiveness of insulin and not to the production of insulin. But that is quite an achievement.

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I believe the AARP publication mentioned not only the Netherlands study but referred to other foreign studies , as well. The Univ of Penn study was the subject of an article by Stacy Burling in the Philadelphia Inquirer. By now there may be others being conducted. Utilizing ablation in Cardiology has been very well received and one can imagine it being utilized in other medical disciplines, as well. Hopefully, in Endocrinology.

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