Does Mayo do PSMA pet scans, and offer proton beam radiation?

Posted by dmd1atl @dmd1atl, Nov 26, 2023

I had robotic RP performed almost 4 weeks ago - pathology determined invasion in both seminal vesicles plus one lymph node. Recommended for ADT plus radiation. Does Mayo offer PSMA pet scans? Does Mayo use proton radiation?

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Mayo Rochester does do the PSMA pet scan in addition to Choline 11 pet scan. They also have the proton beam.

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@jap57

Mayo Rochester does do the PSMA pet scan in addition to Choline 11 pet scan. They also have the proton beam.

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Many thanks!

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@jap57

Mayo Rochester does do the PSMA pet scan in addition to Choline 11 pet scan. They also have the proton beam.

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Arizona Mayo also has Proton Beam therapy.

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I’ll suggest that your question on proton beam therapy should be more refined. I and some others who write here have received proton beam therapy (PBT) as the first level of treatment for Prostate Cancer (PCa). That said, I think your question might be more targeted as “Does Mayo Clinic use PBT for treatment of PCa outside the prostate?” Of course any kind of treatment depends very much on the particulars of your specific situation.

On a quick google search related to PBT and metastatic PCa I did not find a clear answer on Mayo’s website. I did find a clearer statement on Johns Hopkins Hospital website. See: https://clinicalconnection.hopkinsmedicine.org/news/proton-therapy-faqs-for-prostate-cancer#:~:text=It%20is%20a%20curative%20alternative,the%20adjuvant%20or%20salvage%20setting.
It does specifically mention the use of PBT pencil beam scanning as the technology used for PBT delivery. I’m about 99% sure that pencil beam scanning is how my PBT treatment was delivered at Mayo Rochester.

Some in your post prostatectomy situation are referred for ‘salvage radiation’. That may be an attempt to radiate a broader area without specific targets. ~such as if the assumption that PCa cells are likely present but in a quantity (or mass?) below the level that would show on a PSMA PET scan. I believe that metastases that are clear on a PSMA PET scan could be treated with PBT. The advantage of PBT is the ability to ‘target’ a specific site and minimize irradiating not involved tissues and organs.

Best option would be to move forward would be to submit all your records to the Mayo site you prefer (Rochester is bigger, so more docs/appointments). Their style is to have an initial appointment and then add other appointments as dictated by your circumstances and mutually agreed upon treatment.
You might ask (anywhere) what the lag time is between agreement to get PBT and getting on the schedule. With my treatment for PCa their was a needed time to program the equipment. You may also need to have fiducial markers inserted that provide a point to guarantee positioning for multiple PBT treatments . With primary PCa treatment I believe those are inserted into the prostate so not sure of the need in your situation.

I’ll assume that your doctors are also suggesting a course of Androgen Deprivation Therapy (ADT) aka chemical castration. You might search Mayo Connect for others experiences on ADT. There are also some suggestions for a regimen to counter negative side effects of ADT at the prostate cancer research institute http://www.pcri.org

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Hi @dmd1atl, yes, Mayo Clinic offers both PSMA-PET scans and proton radiation.

Gallium Ga 68 PSMA-11 injection is used with a PET scan (positron emission tomography) of prostate-specific membrane antigen (PSMA) positive lesions in men with prostate cancer. It is given in patients with suspected metastasis (cancer that has spread to the other parts of the body) who are candidates for initial treatment, in patients with suspected recurrence (cancer that keeps coming back) based on an increased serum prostate-specific antigen (PSA) level, and for selection in patients with metastatic (cancer that has spread) prostate cancer, for whom lutetium Lu 177 vipivotide tetraxetan PSMA-directed treatment is used.

Here's a video of Dr. Kwon from 11 years ago when Mayo Clinic got FDA Approval for PSMA-PET scans

Both the Minnesota and the Rochester Mayo campuses offer proton beam therapy. You can read more about it here:
- Proton Beam Therapy Program https://www.mayoclinic.org/departments-centers/proton-beam-therapy-program/home/orc-20185488

@dmd1atl, has proton beam therapy been recommended as a treatment for you?

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dmd1atl, Both Rochester and Phoenix offer proton radiation treatments. Mayo Jacksonville has photon only but latest type treatments with it.

All the Mayo's do PSMA and bone scans.

Where did you have your surgery?

I see Collen has posted a web site to review and a You Tube video. As usual, a great monitor who monitors discussions and post helpful information.

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@jap57

Mayo Rochester does do the PSMA pet scan in addition to Choline 11 pet scan. They also have the proton beam.

Jump to this post

Yes, Mayo Rochester does indeed do PSMA-PET scans. Be aware, though—I don’t believe they give you those as long as your cancer is localized and has not become extra capsular (gone outside the prostate gland). I’d invite Colleen, the moderator, to correct me if need be ….. but that is my understanding.

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@jimcinak

I’ll suggest that your question on proton beam therapy should be more refined. I and some others who write here have received proton beam therapy (PBT) as the first level of treatment for Prostate Cancer (PCa). That said, I think your question might be more targeted as “Does Mayo Clinic use PBT for treatment of PCa outside the prostate?” Of course any kind of treatment depends very much on the particulars of your specific situation.

On a quick google search related to PBT and metastatic PCa I did not find a clear answer on Mayo’s website. I did find a clearer statement on Johns Hopkins Hospital website. See: https://clinicalconnection.hopkinsmedicine.org/news/proton-therapy-faqs-for-prostate-cancer#:~:text=It%20is%20a%20curative%20alternative,the%20adjuvant%20or%20salvage%20setting.
It does specifically mention the use of PBT pencil beam scanning as the technology used for PBT delivery. I’m about 99% sure that pencil beam scanning is how my PBT treatment was delivered at Mayo Rochester.

Some in your post prostatectomy situation are referred for ‘salvage radiation’. That may be an attempt to radiate a broader area without specific targets. ~such as if the assumption that PCa cells are likely present but in a quantity (or mass?) below the level that would show on a PSMA PET scan. I believe that metastases that are clear on a PSMA PET scan could be treated with PBT. The advantage of PBT is the ability to ‘target’ a specific site and minimize irradiating not involved tissues and organs.

Best option would be to move forward would be to submit all your records to the Mayo site you prefer (Rochester is bigger, so more docs/appointments). Their style is to have an initial appointment and then add other appointments as dictated by your circumstances and mutually agreed upon treatment.
You might ask (anywhere) what the lag time is between agreement to get PBT and getting on the schedule. With my treatment for PCa their was a needed time to program the equipment. You may also need to have fiducial markers inserted that provide a point to guarantee positioning for multiple PBT treatments . With primary PCa treatment I believe those are inserted into the prostate so not sure of the need in your situation.

I’ll assume that your doctors are also suggesting a course of Androgen Deprivation Therapy (ADT) aka chemical castration. You might search Mayo Connect for others experiences on ADT. There are also some suggestions for a regimen to counter negative side effects of ADT at the prostate cancer research institute http://www.pcri.org

Jump to this post

Thank you - this is very helpful.

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@jamesharrison

Yes, Mayo Rochester does indeed do PSMA-PET scans. Be aware, though—I don’t believe they give you those as long as your cancer is localized and has not become extra capsular (gone outside the prostate gland). I’d invite Colleen, the moderator, to correct me if need be ….. but that is my understanding.

Jump to this post

@jamesharrison, you are correct.

PSMA-PET scans are used
- for patients with suspected metastasis (spread outside the prostate),
- for patients with suspected recurrence (cancer that may have returned) based on an increased serum prostate-specific antigen (PSA) level, and
- for selection in patients with metastatic prostate cancer, for whom lutetium Lu 177 PSMA-directed treatment is used.

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Yes and yes to both of your questions.

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