Does anyone suffer from Crohn's or colitis?

@polly2079
Thank you….do you stop taking once your flare subsides?

@pichulita
I don't stop taking...I have had only 1 small flare up since taking it

I have had Crohn's for over 40 yrs and when my small intestine got involved I tried Low Dose Naltrexone. It turned out to be a miricle drug for me. I am in remission now and I can concentrate on other matters. Some people do have side effects, but I had none. One of your existing drs can perscribe it. Read about it.

@suetex I'm glad to hear you have had success with LDN for Crohn's Disease. Mayo Connect members are encouraged to share our experiences with others, including what has worked for us. But we are not medical professionals, and do not have all the details of anyone's condition, so it is not appropriate to recommend a specific treatment; that is for the patient and their care team to decide

I am very cautious about anecdotal accounts of remission. After a couple of years of treatment, my sister went into a 30 year remission for UC that she sustained with no treatment at all before recurrence. Her remission was so profound that when she had her first colonoscopy at age 50 the doctor questioned if she had had a misdiagnosis. She fell out of remission 10 years later and has been doing well on sulfasalazine. I was in remission for 10 years from CD after surgery, with no treatment at all until I fell out of remission in a spectacularly painful fashion. I've had success with Humira since then, with no side effects and good disease control.

I have done some reading on LDN for Crohn's Disease, and while I don't see any large scale studies on the effectiveness of LDN in inducing remission, there is this promising 2022 study proposal, although no results have been posted as yet.

- Low-dose naltrexone for the induction of remission in patients with mild to moderate Crohn’s disease: protocol for the randomised, double-blinded, placebo-controlled, multicentre LDN Crohn study https://pmc.ncbi.nlm.nih.gov/articles/PMC8996009/

An article from LDN Research Trust did a literature review in 2018, and concluded "Further randomized controlled trials are required to assess the efficacy and safety of LDN therapy in active Crohn's disease in both adults and children."
https://ldnresearchtrust.org/content/ldn-and-crohns-disease
Some other articles I have found:

The Safety and Efficacy of Low-Dose Naltrexone in the Management of Chronic Pain and Inflammation in Multiple Sclerosis, Fibromyalgia, Crohn's Disease, and Other Chronic Pain Disorders
https://pubmed.ncbi.nlm.nih.gov/29377216/
Low dose naltrexone for induction of remission in Crohn's disease
https://pubmed.ncbi.nlm.nih.gov/29607497/
It would be fantastic if there were another medication that was effective in treating CD, especially for pediatrics, but so far there hasn't been large scale testing to show it is effective.