Yes, there have been a lot of user reports of weight gain in the abdomen. I personally think it's just water. Maybe it's the body's way of protecting areas that get frequent injections. I stopped Tymlos two months ago, and I notice that my abdomen is not as soft as before.
from internet:
Abaloparatide (Tymlos) is a synthetic analog of human parathyroid hormone-related protein (PTHrP) used to treat osteoporosis, which can cause an increase in abdominal fat and body weight. The mechanism is linked to it's (action) on calcium levels, metabolism, and parathyroid hormone pathways.
Key Reasons for Increased Fat Cells/Abdominal Fat:
Parathyroid Hormone (PTH) Effects on Fat Cells: Similar to other PTH treatments, abaloparatide can influence adipogenesis (the formation of fat cells) and fat metabolism. Increased fat mass in these cases is often specifically associated with an increase in abdominal adipose tissue.
National Institutes of Health (.gov)
Reduced Fat Cell Death (Apoptosis): High levels of calcium in the blood, which can be induced by parathyroid hormone therapies, are thought to prevent fat cell apoptosis (the natural death of fat cells).
Metabolic Shift: While intended for bone building, PTHrP (1-34) analogs like abaloparatide are involved in adipose tissue remodeling.
National Institutes of Health (.gov)
Secondary Effects: Studies have shown that changes in body composition, including increases in fat mass, can occur, and this has been observed in patients as "abdominal thickening" associated with PTH treatment.
While abaloparatide is effective for increasing bone mineral density and reducing fracture risk, its influence on adipose tissue is a recognized aspect of its metabolic impact.
National Institutes of Health (.gov)
I have been taking Tymlos for 10 months, and I’ve gained about 3 kg. I’ve also noticed that my abdomen and the area around it have become larger. Do you know of any ways to prevent this unwanted weight gain, considering that I need to continue taking Tymlos for my osteoporosis?
I have been taking Tymlos for 10 months, and I’ve gained about 3 kg. I’ve also noticed that my abdomen and the area around it have become larger. Do you know of any ways to prevent this unwanted weight gain, considering that I need to continue taking Tymlos for my osteoporosis?
from internet:
Abaloparatide (Tymlos) is a synthetic analog of human parathyroid hormone-related protein (PTHrP) used to treat osteoporosis, which can cause an increase in abdominal fat and body weight. The mechanism is linked to it's (action) on calcium levels, metabolism, and parathyroid hormone pathways.
Key Reasons for Increased Fat Cells/Abdominal Fat:
Parathyroid Hormone (PTH) Effects on Fat Cells: Similar to other PTH treatments, abaloparatide can influence adipogenesis (the formation of fat cells) and fat metabolism. Increased fat mass in these cases is often specifically associated with an increase in abdominal adipose tissue.
National Institutes of Health (.gov)
Reduced Fat Cell Death (Apoptosis): High levels of calcium in the blood, which can be induced by parathyroid hormone therapies, are thought to prevent fat cell apoptosis (the natural death of fat cells).
Metabolic Shift: While intended for bone building, PTHrP (1-34) analogs like abaloparatide are involved in adipose tissue remodeling.
National Institutes of Health (.gov)
Secondary Effects: Studies have shown that changes in body composition, including increases in fat mass, can occur, and this has been observed in patients as "abdominal thickening" associated with PTH treatment.
While abaloparatide is effective for increasing bone mineral density and reducing fracture risk, its influence on adipose tissue is a recognized aspect of its metabolic impact.
National Institutes of Health (.gov)
@zygote
This is very good infor thank you. I was on tymlos 22 months and gained 8 pounds. Now that said, I was thin - and I liked how I looked (loved my clothes) but was indeed trim and very thin. I must admit, it was not a healhty weight . All my life I could not gain wieght; always having to work at keeping weight.
SInce tymlos, I no longer have to work at keeping weight but I am also eating better.
First off, dense bones weigh more then fragile bones. I know tymlos wieght seems to all be in the belly ( and I was at first sad about my flabby belly) but some if it, is in the bones.
However Let me offer another perspective. In ayurveda ( sister science to yoga /holistic health system of India) fat tissue ( meda dhatu) and bone tissue ( asthi dhatu) are distinct yet directly related to each other;Bone being dependent on healhty fat. Fat tissue acts as a direct source of nutrition for the bones. Think about that... think about all the thin frail women in toruble with their bones / in the offices getting the dexas... Anyway - fat must be in a healthy amount in the body and from healthy foods - healhty fats in the diet ( preferabley with some ghee ). I am not replying in this message about diet - but diet must be a prime component to osteo managment. Hope this helps understadn the fat/bone connection..... and come to peace with the new feeling about how you look and that you are not fracturing. Sending postive energy for yourpath to restored healht.
I’m sorry, but there is no evidence/science that fat helps your bones. It goes against academic foundational science, health andcommon sense. When people get past middle age, they lose the ability to maintain their bones the way they did in the earlier parts of their life. Hormones are required and play a very significant part in getting what is needed to get to the bones. There are two processes involved in bone breakdown. One is the ability to turn over the bon cells and the other requires making them denser.. Much of this is also dependent on your genetics. In addition, what you eat does not directly impact bone quality, your body regulates what it needs to do and you can’t control it through diet alone. Of course, we advocate for the most nutritional diet you can get.
I would proffer that any kind of unnecessary fat is detrimental to health, guided best buy a credentialed doctor or osteopath.
Most of us here have found that our bellies have gotten fatter with the medication use. I wish people hung around to tell us what happens when they finish. Are they able to get their belly back to normal? .
Medicines always have some kind of side effect to go along with them. Not taking the medicine is a risk. Not taking the medicine and falling is a risk. Visceral fat is a risk, especially if it is left to start depositing itself around organs like liver and heart.
Unfortunately, I think the pharmaceutical company is dishonest about the belly fat. Because if us women knew in advance we would be hesitant to take the medicine. I hate what has happened to my waistline, but common sense tells me I would hate fracturing my shoulder if I fell worse!
I’m sorry, but there is no evidence/science that fat helps your bones. It goes against academic foundational science, health andcommon sense. When people get past middle age, they lose the ability to maintain their bones the way they did in the earlier parts of their life. Hormones are required and play a very significant part in getting what is needed to get to the bones. There are two processes involved in bone breakdown. One is the ability to turn over the bon cells and the other requires making them denser.. Much of this is also dependent on your genetics. In addition, what you eat does not directly impact bone quality, your body regulates what it needs to do and you can’t control it through diet alone. Of course, we advocate for the most nutritional diet you can get.
I would proffer that any kind of unnecessary fat is detrimental to health, guided best buy a credentialed doctor or osteopath.
Most of us here have found that our bellies have gotten fatter with the medication use. I wish people hung around to tell us what happens when they finish. Are they able to get their belly back to normal? .
Medicines always have some kind of side effect to go along with them. Not taking the medicine is a risk. Not taking the medicine and falling is a risk. Visceral fat is a risk, especially if it is left to start depositing itself around organs like liver and heart.
Unfortunately, I think the pharmaceutical company is dishonest about the belly fat. Because if us women knew in advance we would be hesitant to take the medicine. I hate what has happened to my waistline, but common sense tells me I would hate fracturing my shoulder if I fell worse!
Yes, there have been a lot of user reports of weight gain in the abdomen. I personally think it's just water. Maybe it's the body's way of protecting areas that get frequent injections. I stopped Tymlos two months ago, and I notice that my abdomen is not as soft as before.
I’m sorry, but there is no evidence/science that fat helps your bones. It goes against academic foundational science, health andcommon sense. When people get past middle age, they lose the ability to maintain their bones the way they did in the earlier parts of their life. Hormones are required and play a very significant part in getting what is needed to get to the bones. There are two processes involved in bone breakdown. One is the ability to turn over the bon cells and the other requires making them denser.. Much of this is also dependent on your genetics. In addition, what you eat does not directly impact bone quality, your body regulates what it needs to do and you can’t control it through diet alone. Of course, we advocate for the most nutritional diet you can get.
I would proffer that any kind of unnecessary fat is detrimental to health, guided best buy a credentialed doctor or osteopath.
Most of us here have found that our bellies have gotten fatter with the medication use. I wish people hung around to tell us what happens when they finish. Are they able to get their belly back to normal? .
Medicines always have some kind of side effect to go along with them. Not taking the medicine is a risk. Not taking the medicine and falling is a risk. Visceral fat is a risk, especially if it is left to start depositing itself around organs like liver and heart.
Unfortunately, I think the pharmaceutical company is dishonest about the belly fat. Because if us women knew in advance we would be hesitant to take the medicine. I hate what has happened to my waistline, but common sense tells me I would hate fracturing my shoulder if I fell worse!
@loriesco
Thank you for your reply and comment, but I received this comment and information exactly under my question I attached above.
Doesn’t that information enough evidence for getting fat and that all the people are complaining of getting fat on their abdomen area under my message?
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Yes, there have been a lot of user reports of weight gain in the abdomen. I personally think it's just water. Maybe it's the body's way of protecting areas that get frequent injections. I stopped Tymlos two months ago, and I notice that my abdomen is not as soft as before.
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2 Reactionsfrom internet:
Abaloparatide (Tymlos) is a synthetic analog of human parathyroid hormone-related protein (PTHrP) used to treat osteoporosis, which can cause an increase in abdominal fat and body weight. The mechanism is linked to it's (action) on calcium levels, metabolism, and parathyroid hormone pathways.
Key Reasons for Increased Fat Cells/Abdominal Fat:
Parathyroid Hormone (PTH) Effects on Fat Cells: Similar to other PTH treatments, abaloparatide can influence adipogenesis (the formation of fat cells) and fat metabolism. Increased fat mass in these cases is often specifically associated with an increase in abdominal adipose tissue.
National Institutes of Health (.gov)
Reduced Fat Cell Death (Apoptosis): High levels of calcium in the blood, which can be induced by parathyroid hormone therapies, are thought to prevent fat cell apoptosis (the natural death of fat cells).
Metabolic Shift: While intended for bone building, PTHrP (1-34) analogs like abaloparatide are involved in adipose tissue remodeling.
National Institutes of Health (.gov)
Secondary Effects: Studies have shown that changes in body composition, including increases in fat mass, can occur, and this has been observed in patients as "abdominal thickening" associated with PTH treatment.
While abaloparatide is effective for increasing bone mineral density and reducing fracture risk, its influence on adipose tissue is a recognized aspect of its metabolic impact.
National Institutes of Health (.gov)
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4 ReactionsI have been taking Tymlos for 10 months, and I’ve gained about 3 kg. I’ve also noticed that my abdomen and the area around it have become larger. Do you know of any ways to prevent this unwanted weight gain, considering that I need to continue taking Tymlos for my osteoporosis?
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Helpful -
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1 Reaction@npoursafar me too 😩
@zygote
This is very good infor thank you. I was on tymlos 22 months and gained 8 pounds. Now that said, I was thin - and I liked how I looked (loved my clothes) but was indeed trim and very thin. I must admit, it was not a healhty weight . All my life I could not gain wieght; always having to work at keeping weight.
SInce tymlos, I no longer have to work at keeping weight but I am also eating better.
First off, dense bones weigh more then fragile bones. I know tymlos wieght seems to all be in the belly ( and I was at first sad about my flabby belly) but some if it, is in the bones.
However Let me offer another perspective. In ayurveda ( sister science to yoga /holistic health system of India) fat tissue ( meda dhatu) and bone tissue ( asthi dhatu) are distinct yet directly related to each other;Bone being dependent on healhty fat. Fat tissue acts as a direct source of nutrition for the bones. Think about that... think about all the thin frail women in toruble with their bones / in the offices getting the dexas... Anyway - fat must be in a healthy amount in the body and from healthy foods - healhty fats in the diet ( preferabley with some ghee ). I am not replying in this message about diet - but diet must be a prime component to osteo managment. Hope this helps understadn the fat/bone connection..... and come to peace with the new feeling about how you look and that you are not fracturing. Sending postive energy for yourpath to restored healht.
-
Like -
Helpful -
Hug
1 ReactionI’m sorry, but there is no evidence/science that fat helps your bones. It goes against academic foundational science, health andcommon sense. When people get past middle age, they lose the ability to maintain their bones the way they did in the earlier parts of their life. Hormones are required and play a very significant part in getting what is needed to get to the bones. There are two processes involved in bone breakdown. One is the ability to turn over the bon cells and the other requires making them denser.. Much of this is also dependent on your genetics. In addition, what you eat does not directly impact bone quality, your body regulates what it needs to do and you can’t control it through diet alone. Of course, we advocate for the most nutritional diet you can get.
I would proffer that any kind of unnecessary fat is detrimental to health, guided best buy a credentialed doctor or osteopath.
Most of us here have found that our bellies have gotten fatter with the medication use. I wish people hung around to tell us what happens when they finish. Are they able to get their belly back to normal? .
Medicines always have some kind of side effect to go along with them. Not taking the medicine is a risk. Not taking the medicine and falling is a risk. Visceral fat is a risk, especially if it is left to start depositing itself around organs like liver and heart.
Unfortunately, I think the pharmaceutical company is dishonest about the belly fat. Because if us women knew in advance we would be hesitant to take the medicine. I hate what has happened to my waistline, but common sense tells me I would hate fracturing my shoulder if I fell worse!
-
Like -
Helpful -
Hug
5 ReactionsHas anyone lost that belly fat after the two years they were on Tymlos? I wondered why I was getting so thick in the gut. Nine months to go.
@loriesco
Thank you for pointing out the lack science backing the bone:fat hypothesis.
@njx58
Were you able to lose any of the belly fat? Or maybe it’s too early to tell. It’s so distressing.
@loriesco
Thank you for your reply and comment, but I received this comment and information exactly under my question I attached above.
Doesn’t that information enough evidence for getting fat and that all the people are complaining of getting fat on their abdomen area under my message?