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Does anyone have CPPD and osteoarthritis

Posted by puff @puff, Nov 12, 2025

I have been diagnosed with CPPD (in my right knee and hands) and osteoarthritis (in my right knee, hands, feet and probably ankles). I recently found out I also have gout in my big toe. I've been prescribed colchicine for CPPD flares but I'm having trouble deciding if my throbbing pain in my hands, toe and knee is CPPD or OA. Is there anyone out there with both CPPD and moderate OA who can help me with how to distinguish how the pain differs in CPPD and OA? Gout flares are so different and easier to distinguish. Colchicine might help reduce the joint damage from CPPD flares but won't likely help my osteoarthritis.

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mikejelenic | @mikejelenic | Apr 16 7:21pm

Dear Puff, I was diagnosed at the cleveland clinic about 9 months ago with CPPD. I had fluid removed from my right knee after experiencing extreme pain when I got out of the shower. Before that I had been receiving a cortisone shot every 90 days. I have had no problem with my knee until I stepped out of the shower. This past January my knee was hurting along with my hip and ankle. My entire right leg was sore and had me up every hour of the night. I got my shot and x-rayed my hip. My hip was fine. My next shot was to be 90 days later, April 15. For the three weeks before the 15th, my right leg was extremely painful. EXTREMELY PAINFUL! MY thigh and calf were unbelievably painful the day before and both my my ancles were swollen.
My wife made me elevate my legs for about 1/2 hour. I then soaked my feet in Epsom salt with Braggs apple cider vinegar. I felt better after about an hour of soaking. About 8 hours all pain was gone. I soaked again last night and will tonight. almost normal.
The things I have read since my diagnosis said magnesium sometimes helps and I have been taking 500 milligrams a day. The epsom salt is magnesium.
Hey puff it worth a try... I am a new person... mike

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roxanne | @rodanne | Apr 17 10:49am

I was diagnosed with CPPD in my neck-left side - excruciating pain 24 hrs a day. I’ve trued chiropractic, PT, steroid injection, 6 different painkillers & 2 - 8 day rounds of Prednisone &Colchisine.. None of it worked. The last thing I was on was Prednisone- 40 mg for 5 days & then tapering which lasted a month. It also included 1/2 of . 6 mg of Colchisine. My last prednisone was 4/13. When I started the taper, the pain was back. Now that I’m off Prednisone, the pain is back with a vengeance! So, I am taking 3600 mg Extra Strength Tylenol. It brings the pain to a 5/10 sometimes. But always wakes me up about 3 am with pain. Dr. suggested a longer time on Prednisone, but my side effects were so bad with the longer dose, that I said no. I had bleeding gums, tremors in my hands, & terrible cramping in my feet & hands.
- Hydro chloroquine was also suggested - however I already have GI issues & am pre glaucoma which can be affected by hydrochloroquin. My CPPD was diagnosed after MRI & CT.
Some background - I’m 85 & have never had pain anywhere before & this started in Feb 2025 when I woke up one morning! I don’t have any arthritis or pain anywhere else. I’m also on Eliquis because I had a Pulmonary Embolism in 2024 after a long flight - I follow all of the precautions, compression stockings, walk every hour & still got the blood clot. I don’t see an end to this. Any suggestions are welcome.

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