Does a positive U1 RNP mean I have an autoimmune disease.

Posted by melissavt @melissavt, Apr 4 5:16am

I recently went to the doctor with a litany of symptoms including fatigue, muscle weakness, brain fog, memory issues, thinning hair etc. Assuming it was hormones or a thyroid, she ran the usual tests. Because I have had Raynaud's Syndrome for 15 years and recent joint issues in my wrists, she included an ANA and CRP test as well with the thought there may be an autoimmune component to my issues.

All the Hormone and thyroid tests and CRP came back normal, but the ANA was slightly positive 1:80 titer.

Last week, she followed up with more autoimmune blood work. SSa, SSb and Anti double strand DNA were negative, but anti U1 RNP was "slightly positive" 2.3 per labs run through Mayo.

She referred me to. Rheumatologist, but the soonest appointment is in Nov 🥺. Of course this has me down the Internet rabbit hole looking for answers.

I understand a positive ANA at that low titer can occur in healthy people. What I was hoping to find was the same for U1 NRP, but I can't. I keep getting stuck in a loop. "A positive anti U1 RNP , while suggestive of an autoimmune immune disease, does not confirm a diagnostic. It's a key marker for MCTD, but can also be found in SLE and other autoimmune diseases.".

Can I have a positive anti U1 RNP result (especially this low) and not have an autoimmune disease?

Can something more benign trigger a positive result?

Interested in more discussions like this? Go to the Autoimmune Diseases Support Group.

Please sign in or register to post a reply.