1. < Prostate Cancer

Do I have Cancer or Not?

Posted by theanomaly @theanomaly, Jan 29 2:16pm

Age 48

Age 47 First PSA was normal January 2024 at 2.48. June 2024 it rose to 3.44 and January 29th 2025 it is 3.58.
June 2024 MRI PIRADS 4 and PIRADS 3 lesions
July 2024 Biopsy - 11 cores benign prostate tissue with chronic inflammation and atrophy. Core F . ***There is a focal region of Atypical glands 0.2mm suspicious for Adenocarcinoma. These cells lack basal cell markers and AMACR amber staining is not definitive.*** I was placed on 6 month active surveillance as Ive already gone through two biopsies looking for cancer cells. Doctor cannot declare me cancer positive or cancer negative. The diagnostic uncertainty is frustrating. Anyone else have a similar experience? Ive been told the lack of basal cells in the Atypical glands is a definite concern.

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

theanomaly | @theanomaly | Feb 5 4:54pm
In reply to @clandeboye1 "@theanomaly Do you have BPH .? Many factors other than cancer can influence the "SMALL "..." + (show)
@clandeboye1

@theanomaly Do you have BPH .? Many factors other than cancer can influence the "SMALL " change in your PSA . Your PSA Doubling time is not concerning . I believe I inquired earlier : " Did you ever get a 2nd or 3 rd opinion of your Biopsy Gleason Score results ?
Are you aware that people with very low PSA numbers can have cancer , while others with very high numbers. Do not have cancer .?
Are you also aware that your PSA can be in the thousands ? . The highest recorded PSA was over 23,000 . Yes : Twenty three thousand .

Jump to this post

I am on both sides of the argument. Part of me agrees with my Urologist. Ive already had two biopsies no definitive diagnosis. I do not want to be turned into a pin cushion if the risk is low. Yet I question if my risk is actually low at all.
PIRADS 4 and a PIRADS 3 lesion on MRI - Rads 4 "Clinically significant cancer is likely to be present" That sounds rather ominous.
Benign prostate tissue with a 0.2mm focus of atypical glands "Suspicious for Adenocarcinoma" These cells lack basal cell markers which is a hallmark in Prostate cancer. Yet others tell me Urologists only really worry about 1cm lesions. If that is the case why rate me with a Rads 4 and a Rads 3. Watchful waiting can be good for older men who will likely die of something other than Prostate cancer. But what about younger men? My PSA has been all over the place since I was 42. It rises up and down with 4.58 being the highest which was in 2017. Yet my PSA has never fallen below 2.5 during that time except January 2024. It then rose back up almost a full point from 2.48 to 3.44 a .96 jump. It then rose again 9 months later to 3.58 which is where it is today. I am asking for 2nd opinions and am working through my patient advocate. I have requested a PSE test and the better low risk Perenial biopsy where Sepsis risk is lower and they can sample even more cores. I wish the experts had a standard of when to worry and when not to worry. Is a 0.2mm A.S.A.P finding not that worrisome since it is not a 1cm finding? I have no idea.

REPLY
View MoreView Less
Please sign in or register to post a reply.