Do I have Cancer or Not?

Posted by theanomaly @theanomaly, 19 hours ago

Age 48

Age 47 First PSA was normal January 2024 at 2.48. June 2024 it rose to 3.44 and January 29th 2025 it is 3.58.
June 2024 MRI PIRADS 4 and PIRADS 3 lesions
July 2024 Biopsy - 11 cores benign prostate tissue with chronic inflammation and atrophy. Core F . ***There is a focal region of Atypical glands 0.2mm suspicious for Adenocarcinoma. These cells lack basal cell markers and AMACR amber staining is not definitive.*** I was placed on 6 month active surveillance as Ive already gone through two biopsies looking for cancer cells. Doctor cannot declare me cancer positive or cancer negative. The diagnostic uncertainty is frustrating. Anyone else have a similar experience? Ive been told the lack of basal cells in the Atypical glands is a definite concern.

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jayhall | @jayhall | 19 hours ago

My PSA was 6 went for a Biopsy and it came back benign. Was placed on surveillance and it doubled to 12 in 6 months. Got put on supplements and retested 3 months later it was 11. They did a PSE and it came back Highly Likely for Prostate cancer. In 10 days I go for my second biopsy for cancer. They can't tell me one way or another, yet till after the second biopsy and genetic tests come back. So yup I'm in a similar situation. You aren't alone.

jeffmarc | @jeffmarc | 15 hours ago

Pirads 4 is considered cancerous adjacent. But your Biopsies Haven’t shown anything. Are they doing an MRI guided biopsy so they hit the Pirads spots? Did they do an anal or perennial biopsy? You can get to more areas with the perennial.

The doctors don’t usually like to let a cancer patients go on AS Without a reason, Based on the information you’ve supplied, it doesn’t look like you’ve even had a Gleason score for your Adenocarcinoma, so were they unable to come up with a Gleason score? Even a 3+3 would tell you something.

northoftheborder | @northoftheborder | 13 hours ago

As a layperson, based just on the info you provided I'd suggest that you're at elevated risk of developing prostate cancer, a bit like being pre-diabetic.

bens1 | @bens1 | 4 hours ago

Per @jayhall, you might want to take the PSE test as it has a 94+% accuracy rate.. I would also think the more evidence you collect, the more definitively you can decide with your doctor what is happening and the more likely your insurance company may be willing to pay for something that you request.