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Decipher Results and Outcomes
I am curious if others have had similar results on their decipher test and outcome. I have added my results and up to date information.
I was diagnosed with a PSA level of 5.5 two years ago. Eight months earlier, it was 2.5. I wasn't feeling well, so I had a complete battery of tests, all of which came back negative. My doctor suggested running a PSA test, which I agreed to, and thus began my journey.
I had a prostatectomy on January 16, 2023. Four lymph nodes and the left seminal vesicles were positive and removed, along with a total of 19 lymph nodes but there was no distant spread Stage 4a. My PSA level was undetectable 8 weeks post-surgery and remained undetectable for the first 6 months. Then it started to rise slowly. When it reached 0.13. Off to the oncologist (who only does pc for 20 plus years) on April 9, 2024, and started Orgovyx.
Before starting radiation therapy, my PSA was undetectable again because of this drug I began radiation on April 23, 2024. After radiation my PSA was >.01 until October 2024 where it went to .02 which freaked me out a bit, not the oncologist.
I had my surgeons appointment in November and my PSA came back >.02 which I think is as low as his lab goes unlike the oncologist. I felt a bit better this time . I would love to head others experiences it helps.
Decipher Redacted_Signed (Decipher-Redacted_Signed-3.pdf)
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@jc76 Thanks for your detailed rresponse . At age 85 ( soon ) I want to stay clear of ADT at all costs .
Accordingly I am investigating Monotherapy SBRT -- 5 Treatments if possible .
MY ALTERNATE PLAN IS EITHER NanoKnife or TULSA PRO .
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1 ReactionHaving been diagnosed via fusion biopsy at a center of excellence with what appeared to be low volume low risk Gleason 3+3 prostate cancer a few months ago, I was blindsided by a “high risk” Decipher result. So have been doing a lot of reading on Decipher. Although I’ve not heard it referred to as the “gold standard”, it does appear that many professionals use it as one of several tools to diagnose prostate cancer and determine treatment both pre and post op. I have likewise seen a number of posts on this site where individuals have altered their treatment plans, from more aggressive to less and vice versa, based on their Decipher results. Suffice to say that my high risk Decipher score has certainly made my decision process more complicated and exhaustive but perhaps that’s not a bad thing at the end of the day.
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5 Reactions@clandeboye1
Bottom line you have to do what is best for you and what you want not what others do.
It is your body and your cancer. I emphasize with you I did not want to be on hormone treatments as was the standard treatment given to me with my diagnosis. The Decipher test was offered and I'm glad I took it. It changed my risk level to low from my originally intermediate risk diagnosis from my biopsies.
Sound like you have the ability to have the options of several different treatments. Many I have no experience or knowledge of.
I wish you luck in your journey.
Have you read my threads on 2nd & 3rd Opinions of your Biopsy result Gleason 3 + 3 = 6
My 1st Transperineal MRI Fusion Biopsy was negative . My MRI was PI Rads 5 .
My 2nd Biopsy was Gleason 3 + 3 + 6 . A 2nd opinion was changed to ALL Gleason 3 + 4 = 7 in all the six target cores . A 3rd opinion changed again to Four Cores Gleason 3 + 3 = 6 and the remaining two cores Glleason 3 + 4 = 7
I suggest , as recommended in Dr. Patrick Walsh's Book " Guide to Surviving Prostate Cancer ", that you get a 2nd or 3rd opinion of your biopsy pathology results .
Finally . I personally would not make any major treatment decisions on a Decipher Score -- It
is only an additional marker BioMARKER !! . The real treatment options are determined by
your Biopsy plus Bone & CT Scans , or PSMA PET CT Scan .