Decipher Result-Interpratation

mauk,
https://decipherbio.com/decipher-prostate/physicians/biopsy-test-report/

It means you have a low risk of metastases, based on the tissue removed by Holep. But you still want to get treatment for you cancer or have it under active surveillance (mpMRIs, annual biopsies…)

.17 is real low and would possibly mean you could go on active surveillance. It would depend on how many cores had 3+4 and what percentage of the cores. Other problematic issues, seen in the biopsy, could require treatment.

Here is a video with Dr. Laurence Klotz, one of the experts on active surveillance. He can give you answers as to why you would or would not be a good candidate for active surveillance.

Very interesting. One confusing thing is that he says around 1:15 in that GG2 is also low risk but then he spends the rest of the discussion on active surveillance in reference to GG1, so it's really hard to know from this video whether a GG2 really qualifies for active surveillance after all.

I believe a caveat expressed in a PCRI.org video is worth repeating.. The data applying the purely objective Decipher score and the correlation/prognosis with current NCCI guidelines is historical. It cannot compensate for PSMA PET CT scans and periodic mpMRIs data that notch back a more pessimistic interpretation. Early detection of metastasis and for example spot radiotherapy, etc, changes the 'over the horizon' prognoses.

I guess it really comes down to whether or not your 3+4 involves multiple cores Or a high percentage of cancer. This is definitely something a good oncologist can decide.

We know there are lots of people with 3+4 going on active surveillance.