Cytology: High-grade urothelial carcinoma to atypical sqamous cells

Posted by hrg @hrg, Sep 10 1:04pm

Hello everyone,
My wife had cytology tests, cytoscopies and a CT urogram. Carcinoma cells were found in the urine but not yet the source.
In particular, three cytology tests found "HIGH-GRADE UROTHELIAL CARCINOMA", but the last one found "ATYPICAL UROTHELIAL CELLS - SQUAMOUS CELL ATYPIA".
We are rather puzzled with the change in the results. Has anyone seen such change in the cytology reports?
Regards,
Hector

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Hi Hector, I'm sorry your wife is going through bladder cancer.
I, too, have high grade non invasive urothelial cancer of the bladder. I just had my cystoscopy at MD Anderson and the doctor said bladder looked good. Then cytology came back:/ same diagnosis for me. No high grade found, my a few atypical cells found. My doctor acts like it's no big deal. I think because it's my bladder and not hers. I'm a 55 yo female that has had to figure so much of this out on my own. It's a shame and makes me mad, too! These doctors should really explain things better and more thoroughly, not leaving any questions in their patients minds. Or having the patient use Dr. Google. Wish I could help more, but all I know is mine was the same this time with atypical cells in the cytology report. Peace Love and Prayers for you both 🙏

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Hi talltxlady,
Thank you for your reply! You are right, the doctors should explain better the findings and be sympathetic with the patient's needs for understanding their medical condition.
I posted my questions because I looked at scientific papers and literature that may explain the change in the cytology results, but no success so far.
My best regards,
Hector

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@hrg, I wonder if you've had a chance to speak with your wife's oncology team about the findings in the meantime. Did you get an explanation about the change is description?

How are you doing? How is your wife doing?

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Hello Colleen,
Thank you for your follow up! My wife doesn't have an oncology team, only the urologist investigating her condition, no diagnostic so far. New tests will be done in October, when we will try to clarify the change in the cytology results.
We are doing fine within the circumstances.
Regards,
Hector

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