Controversial medical diagnosis: overactive gallbladder (hyperkinetic)

I’m very interested to know if there is more to this theory as well! Thank you for posting all this information. I hope you start getting better soon! I’ve been the same way pretty much since I was 16 to about 26 years old it was mostly IBS diarrhea.
From the time I was 26 all the way till 42, I had chronic fatigue syndrome, but it was manageable. I had the best years of my life there!
In 2017 , I was in a motor vehicle accident that ended up leaving me with a fractured C5. While that was healing, I had my first colonoscopy in May 2018. We all know “the body keeps the score“ so my body fell apart. I was going into perimenopause had thyroid disorder. I finally got myself a little regulated. And then I went back to work, and then there was more trauma incurred there, as well as my father living with me for the last 8 years.
It’s been since late November 2022 so present day that I’ve been struggling horribly and fighting viciously.
So I would say 26 years old to 42 years old was great.
I’m just suffering so badly right now, myself. Burping, functional dyspepsia, acid reflux, inability to eliminate without enema’s present and prescription and stool softener. It’s getting so ridiculous!
I’m praying to God that we both start healing for the better. And for good!

Have you ever been tested for either scleroderma or sjogrens?
You seem to be symptomatic for both.

Hida w/cck will tell whether your gallbladder is functioning or not. I assume you don't have any gallstones?
I only ask because numerous things can cause your symptoms. Have you had a EGD and/or esophageal manometry? I have achalasia of my esophagus and have a lot of the symptoms you describe.

Curious if anyone has experience with this. They say that this could cause similar symptoms as under performing gallbladder. Could the high gallbladder ejection rate cause diarhea, stomach pains, and weight gain/inflamation?

Hello. I hope this helps someone.

In January 2025 and possibly the first time in summer of 2023. I began having a series of symptoms that felt like they came on out of nowhere - most notably right upper quadrant pain, bloating after meals, a sudden change in stool color to a rusty orange color, a weird form of reflux, nerve pain in the side of my neck and odd back pain which I know is biliary colic - stabbing pain in right shoulder blade. These symptoms were daily and miserable for nearly 2+ months

Diagnosing went like this:

- H Pylori blood test - inconclusive
- RUQ ultrasound - no stones/sludge - mild thickening
- EGD - normal - mild irritation in antrum portion of stomach
- Encouraged to take PPI (which I did for 10 weeks - uncertain it made much improvement)
- HIDA Scan - 91% EF (Gastro said this was normal
- Colonoscopy in May upon turning 45 - completely clean

Symptoms starting to lessen and become more episodic - lasting for a week but not months ..

Met with general surgeon who previously removed my appendix.

He was unfamiliar with Hyperkinetic or CASPER Gallbladder … but wouldn’t consider removing in absence of stones / sludge or a low ejection fraction HIDA.

Tapped into a medical assistance app through my employer and after a bunch of legwork was connected with someone with more experience with these conditions

Immediate recommendation was cholecystectomy and stated in his experience - symptom resolution at 80% likelihood and symptom improvement almost guaranteed.

I feel for people who have dealt with this for years - I speculate a lot of misdiagnosed IBS is this.

My surgery is scheduled for October and I’ll update upon removal.

Good luck all.

Hello, @chromad06, and welcome to Mayo Clinic Connect. Glad to hear you are getting some answers and have a surgery scheduled.

How have your symptoms been this week while you're awaiting the surgery?