Chronic migraines becoming unbearable

Do you have a neurologist you could contact? I've had this happen and was prescribed a steroid taper. It worked. Good luck!

Last 5 years 24x7 headaches/ migraine (with auras) my "new normal". Head pressure, I found correlation between the weather atmospheric pressure and pressure on brain. I've journal the head pressure with weather app (up or down - accuweather app) atmospheric pressure. If I try to read or work on computer for more than 30 - 45minutes, strong burning sensation top front of brain. Been working with Neurologist (CT Scan and blood work) - learned taking Tylenol to long causes rebound headaches.

Relief - I had first Vyepti Infusion (once every 3 months), Wonderful! Pain level of 8 down to 4, which increased to steady 6 after 30 days. 2nd Vyepti Infusion in couple of weeks. Note: The two previous Migraine Infusion, very strong, but little relief.

Neurologist refer me to Immunologist (Allergy/Immunology). I had a very productive 1st appointment. I keep notes on Symptoms, Current and Previous medications, previous health issues - no sleep history from smart watch, Family history, etc. She requested Lab work (Blood test) for some new things I had not heard before (I can't remember what they were right now). She mentioned that she would need to refer me to another Immunologist for deeper insight.

It has helped me to bring research papers like the following, to get the point across I'm serious.

Is something causing the Brain inflammation - Yes.
https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(24)00438-4
Highlights
SARS-CoV-2 spike protein persists in the skull-meninges-brain axis in COVID-19 patients
Spike protein is sufficient to induce brain pathological and behavioral changes in mice
Spike protein enhances brain vulnerability and exacerbates neurological damage in mice
mRNA vaccines reduce, but do not eliminate, the spike burden

Graphics - (Very Informative)
https://www.cell.com/cms/10.1016/j.chom.2024.11.007/asset/2c765af6-4df2-4090-ba35-07f4e448f475/main.assets/fx1_lrg.jpg
It’s a journey, Best Wishes for Your Journey!
🍀

Hello @jamesl175 and welcome to Mayo Connect. I am sorry to hear about the migraines you've been experiencing. On Connect, there is a discussion group where members discuss migraines specifically. If you post in this group, you might find others with a similar experience. Here is a link to that group:

--Headache Migraine support group
https://connect.mayoclinic.org/group/headache-migraine/
Have you discovered any triggers for your migraines, such as foods/drinks or activities that worsen the pain? Have you consulted with a specialist yet?

You need to go to a neurologist that prescribes and administers Botox for headaches. I am in San Diego and go to Scripps headache clinic. The injections given once every 3 months and covered by insurance will completely (or almost completely) eliminate your migraine. I have been doing this for 3 years now and no longer have migraines.

@hopeful33250 i have not discovered any specific triggers, but they are worse at night. i've had them for years

If you haven’t done so yet, please discuss this A.S.A.P., with your primary care Doctor, and request a referral to a neurologist that specializes in migraine headaches! I did that, a few years ago, and am free of migraines most of the time! Good luck!

I suffered from frequent migraines for many years. I had tried Botox and just about every medicine for them with no relief. Then, as the result of two other problems, I found immediate relief from two sources!

1. Doctors thought I had had a TIA and put me on daily 75mg Plavix - migraine occurance went from 10-12 month to maybe 1 or 2 monthly.

2. A few years later, I had a subdural hematoma as the result of head trauma. I had a Middle meningeal artery (MMA) embolization which is a minimally invasive procedure to treat chronic subdural hematomas by blocking blood flow to the membrane lining the brain. (The procedure involves inserting a catheter through an incision in the wrist or thigh, guiding it to the MMA, and injecting embolic material like medical glue, microparticles, or coils to stop blood flow.) Result - hardly ever have a full migraine anymore. Just a short aura that always had preceeded the headaches maybe 2 times a month now. My neuralogist said that doctors are now looking into this procedure for migraine sufferers!

@adam08 I live in NYC and my Neurologist at the Cornel Weil Hospital has started me on the Botox plan.....I have just had my Second Round. I suffer from a rare type of headache called Hypnic Headaches.....they only come when you are sleeping. usually about two hours after you are in your REM stage....no one knows why they occur other than something wrong with the hypothalamus gland...My first round of Botox wasn't very successful but have been told to hang in there and that it gets better with every round....glad to read Botox has been successful. My second round has been much more successful.

@duchess926
Qulipta and Ubrelvy have decreased my migraines greatly.
Qulipta prevents-take at bedtime?
Ubrelvy recovers from an attack.
Find a neurologist who can treat migraines-NEVER accept BACLAFEN as a treatment for any sort of headache. I ended up in the hospital for 19 days and 3 surgeries.

@jamesl175
Have you consulted with any specialists? There may be some help available.