Chemo and hormone therapy - effects on thyroid

My husband is responding well to triple therapy for his stage 4 prostate cancer. 5 of 6 rounds of chemo done!

Before this last round, they also checked his thyroid as it hadn’t been done since before the first round. He has hypothyroidism and has been on meds for that for years now. His numbers for that jumped and they have adjusted his thyroid medication.

This last round he was prescribed a non-steroidal anti inflammatory to help with the pain the first 7 days after treatment and it’s helped a lot. Apparently it can affect thyroid meds, but his numbers had changed before starting that.

I wonder if this could account for some of the fatigue in addition to what would be from the chemo? Anyone else?