CAR-T - Looking for statistical data for over 70 age group

Hello @myfablife - I was diagnosed with AML a few months ago. It is my understanding that Car T is not a treatment option for this disease.

Venclexta 50mg everyday
Decitabine infusion every 3weeks 5x a week.
I will f/u with my oncologist soon🙏🏻I am still in remission.
Thanks for all your help.. I am just trying to understand this dx.

Sorry for my delay in writing. My husband will undergo CAR-T shortly. He will enter a clinical trial in Toronto. CAR-T hasn’t been that successful for CLL, but Princess Margaret Hospital is hoping this trial will offer a better outcome. We had to wait for funding ($1 mill per patient) and a protocol change (no washout period). I imagine he will have the cell collection by the end of this month. In the meantime two drugs are keeping him “healthy” as we wait for the trial. His docs are amazed. The combo hasn’t been used before. Sometimes these breaks in disease progression are about trial and error. My husband is back in the tennis court (age 75) and this makes him happy. Personally, I don’t like the word “caregiver”. As a spouse I think we are as equally affected as the patient. There needs to be a better word! We just went on a week long cruise. We vowed not to discuss my husband’s CLL journey, because you can really get mired in the medical stuff! It was very healthy for both of us!

From my understanding, Chimeric antigen receptor (CAR) T-cell therapies have been approved for the treatment of B-cell malignancies and multiple myeloma, but it’s very challenging to treat myeloid malignancies with this type of therapy. Research on CAR T-cell therapy is progressing rapidly to improve cancer treatment and expand its use to more cancers. So hope may be on the horizon but not quite available yet.
I know you’re desperately trying to find options to treat your AML since the bone marrow transplant isn’t a viable option for you due to your liver transplant and CKD. Those conditions can be further complicated by the rigors of transplant, and vice versa. What medications are you currently taking to keep the AML under control?

Hi can CarTCell work for AML patients..anyone know very interested to know

Welcome to Connect, @cdsarmiento. Thank you so much for sharing your husband’s experience with his CAR-T therapy adventure at the age of 84. This is really reassuring and encouraging for anyone who maybe considering the procedure. It’s not an easy journey but well worth the effort to have such a positive outcome and I’m so happy for your husband that he’s doing so well.
Did he have any issues with the pre-conditioning chemo or after the infusion of cells?

Hello. My Lymphoma is Stage II nodular sclerosing Hodgkin which is refractory but stable. It was diagnosed in 2020, so I have been in treatment for four years now. Currently I am being infused with Nivolumab every two weeks and bendamustine every four weeks. Should this regimen either fail or for other reasons need to be changed, I am very interested in CAR-T cell therapy. At age 84, your post gives me encouragement that this may work for me if needed. Thank you for your post and I hope to hear updates!

My husband is 86 years old and had CAR T-cell therapy (December 2022) at age 84. He did very well and has been in remission ever since…no sign of Lymphoma anywhere. Go for it!

Hi @brayton, please note that your phone number has been removed. It is recommended to use the secure private message function and not post personal contact information on the public forum.

However, I'd also like to point out the benefit of sharing here in the support group where you will receive support and information from several people and we can all learn from each other.

Brayton, when do you start CAR-T cell therapy?

Thank you.
Would like to talk to you on the phone. My name is Brayton. I am 70. Car T is last chance after chemo burn out.
I am a fighter.